Shi Xuan Leong, Caleb E. Griesbach, Rui Zhang, Kourosh Darvish, Yuchi Zhao, Abhijoy Mandal, Yunheng Zou, Han Hao, Varinia Bernales, Alán Aspuru-Guzik
{"title":"Steering towards safe self-driving laboratories","authors":"Shi Xuan Leong, Caleb E. Griesbach, Rui Zhang, Kourosh Darvish, Yuchi Zhao, Abhijoy Mandal, Yunheng Zou, Han Hao, Varinia Bernales, Alán Aspuru-Guzik","doi":"10.1038/s41570-025-00747-x","DOIUrl":null,"url":null,"abstract":"The past decade has witnessed remarkable advancements in autonomous systems, such as automobiles that are evolving from traditional vehicles to ones capable of navigating complex environments without human intervention. Similarly, the rise of self-driving laboratories (SDLs), which leverage robotics and artificial intelligence to accelerate discovery, is driving a paradigm shift in scientific research. As SDLs evolve to expand the scope of chemical processes that can be performed, it is essential to bring safety to the forefront to ensure that the necessary safeguards are in place to mitigate against potential accidents that range from near-misses to catastrophic failures. This Perspective examines the development trajectory of SDLs, juxtaposing their development with those of other autonomous technologies, with a particular focus on safety. We explore current safety status and concerns, identify opportunities for innovation to shape this rapidly evolving landscape, and reflect on the actions the SDL community can take moving forward. Self-driving laboratories promise accelerated discovery. As the scope of chemical processes and level of autonomy in these laboratories expand, a comprehensive safety framework is essential. We discuss here the safety development trajectory of SDLs, identifying opportunities for innovation to shape this rapidly evolving landscape.","PeriodicalId":18849,"journal":{"name":"Nature reviews. Chemistry","volume":"9 10","pages":"707-722"},"PeriodicalIF":51.7000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews. Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.nature.com/articles/s41570-025-00747-x","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The past decade has witnessed remarkable advancements in autonomous systems, such as automobiles that are evolving from traditional vehicles to ones capable of navigating complex environments without human intervention. Similarly, the rise of self-driving laboratories (SDLs), which leverage robotics and artificial intelligence to accelerate discovery, is driving a paradigm shift in scientific research. As SDLs evolve to expand the scope of chemical processes that can be performed, it is essential to bring safety to the forefront to ensure that the necessary safeguards are in place to mitigate against potential accidents that range from near-misses to catastrophic failures. This Perspective examines the development trajectory of SDLs, juxtaposing their development with those of other autonomous technologies, with a particular focus on safety. We explore current safety status and concerns, identify opportunities for innovation to shape this rapidly evolving landscape, and reflect on the actions the SDL community can take moving forward. Self-driving laboratories promise accelerated discovery. As the scope of chemical processes and level of autonomy in these laboratories expand, a comprehensive safety framework is essential. We discuss here the safety development trajectory of SDLs, identifying opportunities for innovation to shape this rapidly evolving landscape.
期刊介绍:
Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.