Utility of inhaled nitric oxide for pulmonary hypertension in cyanotic congenital heart disease: a cohort study with propensity score matching.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2026-06-01 Epub Date: 2025-08-18 DOI:10.4103/mgr.MEDGASRES-D-25-00062
Xiaofeng Wang, Chenyu Li, Shilin Wang, Zhiyuan Zhu, Qinnan Chen, Ruihuan Shen, Xu Wang
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引用次数: 0

Abstract

JOURNAL/mgres/04.03/01612956-202606000-00001/figure1/v/2025-08-18T154854Z/r/image-tiff Pulmonary hypertension can lead to hemodynamic instability and worsen the outcome after the repair of cyanotic congenital heart disease with decreased pulmonary blood flow. However, the safety and effectiveness of targeted therapy, such as inhaled nitric oxide, remain controversial. This retrospective cohort study included patients who underwent corrective repair for tetralogy of Fallot, double outlet right ventricle, or pulmonary atresia with ventricular septal defect with hypoplastic pulmonary vasculature at Fuwai Hospital between 2014 and 2021. Patients were divided into a regular treatment group and a combined treatment group depending on whether inhaled nitric oxide was prescribed. The improvement in low cardiac output syndrome within 24 hours after surgery and the main clinical outcomes during hospitalization were compared between the two groups after 1:1 propensity score matching. Compared with those in the regular treatment group, both the incidence of low cardiac output syndrome and the rate of renal replacement therapy were lower in the combined treatment group. Inhaled nitric oxide therapy is effective in the treatment of patients with pulmonary hypertension after corrective repair of cyanotic congenital heart disease.

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吸入一氧化氮治疗紫绀型先天性心脏病肺动脉高压的效用:一项倾向评分匹配的队列研究
肺动脉高压可导致血流动力学不稳定,恶化青紫型先天性心脏病修复后肺血流减少的预后。然而,靶向治疗的安全性和有效性,如吸入一氧化氮,仍然存在争议。本回顾性队列研究纳入了2014年至2021年阜外医院因法洛四联症、双出口右心室或肺闭锁合并室间隔缺损伴肺血管发育不全而进行矫正修复的患者。根据是否使用吸入型一氧化氮,将患者分为常规治疗组和联合治疗组。经1:1倾向评分匹配,比较两组患者术后24小时内低心输出量综合征的改善情况及住院期间主要临床结局。与常规治疗组相比,联合治疗组低心输出量综合征发生率和肾脏替代治疗率均较低。吸入一氧化氮治疗青紫型先天性心脏病矫治术后肺动脉高压是有效的。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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