Plant-derived phenolics as regulators of nitric oxide production in microglia: mechanisms and therapeutic potential.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2026-06-01 Epub Date: 2025-08-18 DOI:10.4103/mgr.MEDGASRES-D-25-00058
Naira Sahakyan
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引用次数: 0

Abstract

Neuroinflammation plays a critical role in the pathogenesis of neurodegenerative diseases with microglial activation and excessive nitric oxide production contributing significantly to disease progression. Plant-derived phenolic compounds have emerged as promising neuroprotective agents due to their ability to modulate the key signaling pathways, including nuclear factor-κB, mitogen-activated protein kinases, nuclear factor erythroid 2-related factor 2, and phosphoinositide 3-kinase/protein kinase B. These bioactive molecules effectively suppress inducible nitric oxide synthase expression, reduce oxidative and nitrosative stress, and restore immune homeostasis. Additionally, these natural phenolic compounds are able to regulate mitochondrial function and autophagy, further supporting their therapeutic potential in central nervous system disorders. The presented review aimed to explain the key known mechanisms of action of plant-origin phenolics, in order to evaluate their potential in developing treatments and preventing central nervous system diseases.

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植物源性酚类物质作为小胶质细胞一氧化氮产生的调节剂:机制和治疗潜力。
神经炎症在神经退行性疾病的发病机制中起着至关重要的作用,小胶质细胞的激活和过量的一氧化氮的产生显著地促进了疾病的进展。植物源性酚类化合物具有调节关键信号通路的能力,包括核因子-κB、丝裂原活化蛋白激酶、核因子2-相关因子2和磷酸肌苷3-激酶/蛋白激酶b。这些生物活性分子有效抑制诱导型一氧化氮合酶的表达,减少氧化和亚硝化应激,恢复免疫稳态,因此成为有前景的神经保护药物。此外,这些天然酚类化合物能够调节线粒体功能和自噬,进一步支持其在中枢神经系统疾病中的治疗潜力。本文综述了植物源性酚类物质的主要作用机制,以评价其在中枢神经系统疾病的治疗和预防方面的潜力。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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