Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2026-06-01 Epub Date: 2025-08-18 DOI:10.4103/mgr.MEDGASRES-D-25-00020

Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao

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Abstract

JOURNAL/mgres/04.03/01612956-202606000-00002/figure1/v/2025-08-18T154854Z/r/image-tiff Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affiliated Hospital of Chengde Medical College examined the effect of hydrogen-oxygen on sleep disorders. Sixty-six participants with sleep disorders were randomly divided into a control group and a hydrogen-oxygen group that received nasal gas inhalation for seven days. Sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index, Self-Rating Depression Scale, and Self-Rating Anxiety Scale. An Actiwatch helped evaluate the effects of two kinds of gas inhalation on total sleep time, sleep efficiency, and the wake time of patients with sleep disorders. The control group showed no significant changes in sleep parameters during treatment, whereas the hydrogen-oxygen group showed significant improvements in total sleep time and sleep efficiency on days 3, 5, and 7 and significant reductions in wake time on days 3 and 7. Compared with those in the control group, the total sleep time was greater and the wake time was lower in the hydrogen-oxygen group. After 7 days, the scores of the Pittsburgh Sleep Quality Index and Self-Rating Depression Scale in the hydrogen-oxygen group were lower than those in the control group, whereas the Self-Rating Anxiety Scale scores did not differ significantly. Hydrogen-oxygen therapy effectively improved sleep disorders by reducing wake time, relieving psychological stress, and enhancing sleep quality. The study was registered in the Chinese Clinical Trial Registry (registration No. ChiCTR2400084103).

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氢氧吸入对睡眠障碍和异常情绪的影响：一项单盲、随机对照试验。

睡眠障碍与多种慢性疾病相关。虽然氢具有抗炎、抗氧化和抗纤维化作用，并在疾病管理中有潜在的应用，但它对睡眠障碍的影响尚不清楚。这项单盲、随机对照临床试验于2022年9月至2023年7月在解放军总医院第二医学中心和承德医学院附属医院进行，研究了氢氧对睡眠障碍的影响。66名患有睡眠障碍的参与者被随机分为对照组和氢氧组，后者接受为期七天的鼻腔气体吸入。采用匹兹堡睡眠质量指数、抑郁自评量表和焦虑自评量表评估睡眠质量和情绪。Actiwatch帮助评估了两种气体吸入对睡眠障碍患者的总睡眠时间、睡眠效率和清醒时间的影响。对照组在治疗过程中睡眠参数没有明显变化，而氢氧组在第3、5和7天的总睡眠时间和睡眠效率有显著改善，在第3和7天的醒着时间有显著减少。与对照组相比，氢氧组的总睡眠时间更长，清醒时间更短。7天后，氢氧组匹兹堡睡眠质量指数和抑郁自评量表得分低于对照组，而焦虑自评量表得分无显著差异。氢氧疗法通过减少清醒时间，缓解心理压力，提高睡眠质量，有效改善睡眠障碍。本研究已在中国临床试验注册中心注册(注册号：ChiCTR2400084103)。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.