Comparison between paravertebral injections of ozone and epidural injections of corticosteroids used in the treatment of lumbosacral pain: scoping review.
Pedro Iván Arias-Vázquez, Rosa Giannina Castillo-Avila, Ricardo Quezada-González, Karen Hernández-Gil, Blanca Gabriela Legorreta-Ramírez, María Antonieta Ramírez-Wakamatzu
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引用次数: 0
Abstract
Paravertebral ozone injections have been used in the treatment of lumbosacral pain with or without radicular irradiation and have been reported to be effective in reducing pain when compared with placebo, physiotherapy programs or drug treatments; nevertheless, their effectiveness in comparison with minimally invasive procedures using corticosteroids is unknown. The main objective of this review was to explore the role of paravertebral ozone injections in the treatment of lumbosacral pain with radicular irradiation in comparison with minimally invasive procedures using corticosteroids. A systematic search was performed in electronic databases including PubMed, EMBASE, Central Cochrane and Web of Science, from January 2000 to December 2024; for clinical studies that compared paravertebral ozone injections with minimally invasive procedures using corticosteroids in the treatment of lumbosacral pain with radicular irradiation and were performed using the methodology of a scoping review. Four clinical trials met the inclusion criteria and were included in this review, gathering a total of 501 individuals. In the within-group comparison of every study, statistically significant reduction in pain was observed in both interventions. No side effects or serious adverse reactions were reported in the treated patients. Paravertebral ozone injections appear to have a favorable therapeutic effect in reducing pain in the short and medium terms, in individuals with lumbosacral pain with radicular irradiation, and this effect appears to be similar to that of epidural corticosteroid injections. No definitive recommendations are possible, for more clinical trials are needed to conduct meta-analytic reviews that clarify the results of this comparison.
椎旁臭氧注射已被用于治疗腰骶疼痛,有或没有神经根照射,据报道,与安慰剂、物理治疗方案或药物治疗相比,在减轻疼痛方面有效;然而,与使用皮质类固醇的微创手术相比,它们的有效性尚不清楚。本综述的主要目的是探讨椎旁臭氧注射在神经根照射治疗腰骶疼痛中的作用,并与使用皮质类固醇的微创手术进行比较。系统检索2000年1月至2024年12月PubMed、EMBASE、Central Cochrane和Web of Science等电子数据库;临床研究比较了椎旁臭氧注射与使用皮质类固醇治疗腰骶神经根照射疼痛的微创手术,并采用了范围审查的方法。四项临床试验符合纳入标准,纳入本综述,共收集了501人。在每项研究的组内比较中,两种干预均观察到统计学上显著的疼痛减轻。治疗患者无不良反应或严重不良反应。椎旁臭氧注射似乎在短期和中期减轻腰骶痛患者神经根照射的疼痛方面有良好的治疗效果,这种效果似乎与硬膜外皮质类固醇注射相似。没有明确的建议是可能的,因为需要更多的临床试验来进行荟萃分析评价,以澄清这一比较的结果。
期刊介绍:
Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.