Samarium-doped hydroxyapatite: An effective approach for enhancing biomineralization in dental caries management.

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-11-01 Epub Date: 2025-08-08 DOI:10.1016/j.jobcr.2025.07.026

C P Harini, Radha Gosala, Ramya Ramadoss

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引用次数: 0

Abstract

Background: Dental caries is a widespread non-communicable disease caused by interactions among acidogenic bacteria, fermentable carbohydrates, and host factors, leading to tooth demineralization. In dentin caries, this process exposes dentinal tubules, causing sensitivity and structural degradation. Despite available agents, effective dentin remineralization remains a challenge. Recent studies highlight samarium-doped hydroxyapatite (Sm-HAp) as a potential biomaterial for promoting remineralization.

Aim: To synthesize and characterize the samarium doped hydroxyapatite (Sm-HAp) as a potential agent in dentin remineralization.

Materials and methods: Sm-HAp was synthesized via wet-chemical precipitation. Characterization was performed using SEM for morphology, FTIR for functional groups, and XRD for crystalline features. MTT assay evaluated for biocompatibility and in vitro mineralization analyzed on human tooth samples.

Results: SEM showed flake-like, and needle-shaped crystals. XRD indicated the formation Sm doped hydroxyapatite without any additional phase, which further confirmed by FTIR. MTT assay showed >85 % cell viability, confirming high biocompatibility and also an efficient dentine mineralization was observed with Sm-HAp treatment.

Conclusion: Sm-HAp demonstrates favorable structural, chemical, and biological properties, supporting its potential as a dentin remineralizing agent in dental caries management.

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掺钐羟基磷灰石：龋治疗中加强生物矿化的有效方法。

背景：龋齿是一种广泛存在的非传染性疾病，由产酸细菌、可发酵碳水化合物和宿主因素相互作用引起，导致牙齿脱矿。在牙本质龋齿中，这个过程暴露了牙本质小管，导致敏感和结构退化。尽管有可用的药物，有效的牙本质再矿化仍然是一个挑战。最近的研究表明，钐掺杂羟基磷灰石（Sm-HAp）是一种潜在的促进再矿化的生物材料。目的：合成并表征钐掺杂羟基磷灰石（Sm-HAp）作为牙本质再矿化的潜在剂。材料与方法：采用湿化学沉淀法合成Sm-HAp。用SEM表征形貌，FTIR表征官能团，XRD表征晶体特征。MTT法评价了人类牙齿样品的生物相容性和体外矿化分析。结果：扫描电镜显示片状、针状晶体。XRD分析表明形成了Sm掺杂的羟基磷灰石，没有任何附加相，FTIR进一步证实了这一点。MTT实验显示细胞存活率为> 85%，证实了Sm-HAp处理的高生物相容性和有效的牙本质矿化。结论：Sm-HAp具有良好的结构、化学和生物学特性，支持其作为牙本质再矿化剂在龋齿治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.