Assessment of the Risk of Microplastics on Gill and Gut Health and Subsequent Pathogen Susceptibility in the Goldfish Model.

IF 3.1 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ho Sung Kim, Bohyun Yun, Yongjoon Yoon, Jeong Woo Park, Jimin Hyun, BoMi Ryu, Aaron M Yerke, Sungmin Hwang, Ki Hwan Moon
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Abstract

Microplastics are pervasive pollutants in aquatic ecosystems, yet their effects on fish tissues remain insufficiently characterized. Our study investigates the impact of polystyrene microplastics (0.5 and 2 μm) on the gill and intestinal tissues of goldfish (Carassius auratus), with a focus on inflammatory responses and pathogen susceptibility. Following two weeks of exposure, histological and molecular analyses revealed increased filament cartilage thickness in gills, enhanced villus thickness and goblet cell numbers in intestines, and upregulation of immune- and oxidative stress-related genes. Exposure to 0.5 μm microplastics significantly reduced survival after Edwardsiella piscicida infection, indicating increased vulnerability to pathogens. These findings highlight the immunotoxic effects of microplastics and their potential to compromise fish health in contaminated environments.

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金鱼模型中微塑料对鳃和肠道健康的风险评估及随后的病原体敏感性
微塑料是水生生态系统中普遍存在的污染物,但它们对鱼类组织的影响尚未得到充分的研究。本研究探讨了聚苯乙烯微塑料(0.5 μm和2 μm)对鲫鱼(Carassius auratus)鳃和肠道组织的影响,重点研究了炎症反应和病原体敏感性。暴露两周后,组织学和分子分析显示鳃的细丝软骨厚度增加,肠绒毛厚度和杯状细胞数量增加,免疫和氧化应激相关基因上调。暴露于0.5 μm微塑料显著降低了鱼酸爱德华氏菌感染后的存活率,表明对病原体的易感性增加。这些发现强调了微塑料的免疫毒性作用及其在污染环境中危害鱼类健康的潜力。
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来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
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