{"title":"When huffing and puffing Ca2+ goes global, breast cancer cells are unmoved.","authors":"Woo Young Chung, Shmuel Muallem","doi":"10.1083/jcb.202507062","DOIUrl":null,"url":null,"abstract":"<p><p>In this issue, Militsin et al. (https://doi.org/10.1083/jcb.202411203) reveal how STIM1 and STIM2-beyond their typical role as ER Ca2+ sensors that activate Orai1-control IP3R-mediated Ca2+ dynamics, thereby regulating breast cancer cell migration and invasion.</p>","PeriodicalId":15211,"journal":{"name":"Journal of Cell Biology","volume":"224 9","pages":""},"PeriodicalIF":6.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1083/jcb.202507062","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/19 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this issue, Militsin et al. (https://doi.org/10.1083/jcb.202411203) reveal how STIM1 and STIM2-beyond their typical role as ER Ca2+ sensors that activate Orai1-control IP3R-mediated Ca2+ dynamics, thereby regulating breast cancer cell migration and invasion.
期刊介绍:
The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.