Prevalence and distribution of human papillomavirus in genital warts in Can Tho City, Vietnam: a cross-sectional study.

IF 2.8 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2025-08-18 DOI:10.1186/s13027-025-00685-9

Lac Thi Kim Ngan, Huynh Van Ba, Dao Hoang Thien Kim, Dang Tran Dang Khoa, Nguyen Tan Hung, Pham Thi Bao Tram, Nguyen Thi Thuy Trang, Nguyen Hoang Khiem, Pham Thanh Thao, Truong Dieu Hien, Le Van Dat, Hung Do Tran, Nguyen Van Lam, Hung Gia Tran

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引用次数: 0

Abstract

Background: Human papillomavirus (HPV) is the major causative agent of genital warts and various anogenital cancers. In Vietnam, limited data exists on HPV genotype prevalence and distribution. This study aimed to determine the prevalence and distribution of HPV types among patients with genital warts in Can Tho City and to explore their associations with demographic and clinical characteristics.

Methods: A cross-sectional study was conducted at Can Tho Dermatology Hospital with 109 patients diagnosed with genital warts. HPV genotyping was performed using real-time PCR and reverse dot blot hybridization to detect both the low- and high-risk HPV types. Associations between HPV types and variables such as age, sex, and lesion site were analyzed statistically.

Results: HPV was detected in 89% of the patients. The low-risk types HPV11 (50.5%) and HPV6 (47.4%) were the most common. The high-risk types, HPV51 (30.9%) and HPV52 (20.6%), were frequent, especially in females (83.6% vs. 63.3% in males, p = 0.030). Co-infections occurred in 71.6% of females and 60% of males. Lesion location correlated with HPV type distribution.

Conclusions: The high prevalence of both low- and high-risk HPV types highlights the need for enhanced vaccination coverage and continued HPV surveillance. These findings provide critical data for developing HPV prevention strategies in Vietnam.

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越南芹苴市生殖器疣中人乳头瘤病毒的流行和分布：一项横断面研究。

背景：人乳头瘤病毒（HPV）是生殖器疣和各种肛门生殖器癌的主要病原体。在越南，关于HPV基因型流行和分布的数据有限。本研究旨在确定芹苴市生殖器疣患者中HPV类型的患病率和分布，并探讨其与人口统计学和临床特征的关系。方法：对在灿苴皮肤病医院诊断为生殖器疣的109例患者进行横断面研究。采用实时荧光定量PCR和反向斑点杂交技术进行HPV基因分型，检测低危型和高危型。对HPV类型与年龄、性别、病变部位等变量之间的关系进行统计学分析。结果：89%的患者检出HPV。低危型HPV11（50.5%）和HPV6（47.4%）最为常见。高危型HPV51型（30.9%）和HPV52型（20.6%）较多，以女性居多（83.6% vs.男性63.3%,p = 0.030）。女性共感染71.6%，男性共感染60%。病变部位与HPV型别分布相关。结论：低风险和高风险HPV类型的高患病率突出了加强疫苗接种覆盖率和持续HPV监测的必要性。这些发现为越南制定HPV预防策略提供了关键数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.