Qiaoqiao Kong, Yixiang Jiang, Xiang Li, Xuejing Lu
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引用次数: 0
Abstract
Aging is a significant risk factor for various ophthalmic diseases, which can lead to vision loss. With the worldwide elderly population expanding, it is essential for researchers to elucidate the mechanisms underlying the progression of ocular diseases and to ascertain methods for their prevention or deceleration. The five principal age-related eye disorders (AREDs) consist of glaucoma, dry eye syndrome (DES), diabetic retinopathy (DR), cataracts, and age-related macular degeneration (AMD). A sustained subclinical low-grade inflammation has been observed at the ocular surface of elderly individuals who identify as "healthy." In these instances, an imbalance in para-inflammatory processes, which are essential for preserving tissue homeostasis in response to environmental injuries or insults, results in ocular surface system dysfunction, commonly referred to as InflammAging. Corneal and conjunctival epithelial cells express a variety of immune-related recognition receptors, including toll-like receptors (TLRs). At the ocular surface, TLRs play an active role in immunological instruction and innate defense mechanisms. The function of TLRs in AREDs is summarized here. In addition to discussing potential solutions and challenges in the clinical use of TLR inhibitors, future challenges will also be addressed.
期刊介绍：
Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas:
-Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states
-Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs
-Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents
-Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain
-Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs
-Muscle-immune interactions during inflammation [...]
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