A Comparative Evaluation of Biomimetic Remineralization Potential of Enamel White Spot Lesions - An In Vitro Study.

Abstract

Introduction: The remineralization potential of three recent remineralizing agents on white spot lesions (WSLs) was compared and evaluated using the Vicker's microhardness testing machine. This short study aims to evaluate and compare the remineralization potential of recently introduced remineralizing agents like Curodont Protect gel, GC Tooth Mousse Plus, and Dente 91 on the surface hardness of WSLs in human teeth.

Methods and materials: Thirty single-rooted human premolars (BBDCODS/IEC/09/2022), extracted due to periodontal or orthodontic reasons, were chosen for this study. The teeth were decoronated at the cemento-enamel junction level. Samples were then mounted in auto-polymerization acrylic resin. All the groups were subjected to a demineralization process to induce WSLs. A post-demineralization Vicker hardness test was performed, followed by random allocation to the three groups. The three groups were namely self-assembling peptide (P11-4), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and nanohydroxyapatite. A post-remineralization Vickers hardness test was conducted to evaluate the remineralization potential of the tested agents.

Result: An analysis of variance was performed to determine the significant difference in Vickers microhardness. Self-assembling peptide (P11-4) showed the highest microhardness value.

Conclusion: Self-assembling peptide (Curodont Protect gel) was more efficient than nanohydroxyapatite (Dente-91) and CPP-ACP (GC Tooth Mousse Plus) for the prevention of WSLs.