Preventive Effect of Helicobacter pylori Eradication on Osteoporosis in Females: A 20-Year Prospective Observational Cohort Study.

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2025-08-18 DOI:10.5009/gnl250164
Yeejin Kim, Yonghoon Choi, Nayoung Kim, Eun-Bi Jeon, Sung Hye Kong, Jeong Hwan Lee, Ho-Kyoung Lee, Yu Kyung Jun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Soyeon Ahn
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引用次数: 0

Abstract

Background/aims: The relationship between Helicobacter pylori (HP) eradication and osteoporosis development remains inadequately elucidated. This study aimed to ascertain whether HP eradication therapy confers protective effects against osteoporosis progression.

Methods: Subjects without osteoporosis who underwent esophagogastroduodenoscopy with concurrent HP testing were prospectively recruited between May 2003 and February 2023 at Seoul National University Bundang Hospital. Participants were stratified into two cohorts: those with successful HP eradication and those without. Osteoporosis was diagnosed using dual-energy X-ray absorptiometry, and the risk of osteoporosis was assessed using Cox proportional hazards regression analysis.

Results: The successfully eradicated cohort comprised 730 individuals (mean age, 56.4 years; 67.5% female), compared with 116 individuals (mean age, 56.2 years; 74.1% female) in the non-eradicated cohort. Osteoporosis occurred in 179 subjects (24.5%) in the eradicated group and in 40 subjects (34.5%) in the non-eradicated group. Significant risk factors for osteoporosis included female sex (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.93 to 5.05; p<0.001), advanced age (HR, 1.08; 95% CI, 1.06 to 1.10 per year; p<0.001), and persistent HP infection (HR, 1.60; 95% CI, 1.13 to 2.28; p=0.009). In subgroup analyses according to sex and age, HP eradication demonstrated a significant reduction in osteoporosis risk in females (p=0.005) than in males, especially among females aged ≥50 years (p=0.003). However, this change was not pronounced in males.

Conclusions: HP eradication may serve as a preventive intervention against osteoporosis development, particularly among female subjects (ClinicalTrials.gov: NCT06818591).

根除幽门螺杆菌对女性骨质疏松症的预防作用:一项20年前瞻性观察队列研究。
背景/目的:幽门螺杆菌(HP)根除与骨质疏松症的关系尚不清楚。本研究旨在确定HP根除治疗是否对骨质疏松症进展具有保护作用。方法:前瞻性招募2003年5月至2023年2月在首尔国立大学盆唐医院接受食管胃十二指肠镜检查并同时进行HP检查的无骨质疏松患者。参与者被分成两组:成功根除HP的组和没有根除HP的组。采用双能x线骨密度仪诊断骨质疏松,采用Cox比例风险回归分析评估骨质疏松的风险。结果:成功根除组共730例(平均年龄56.4岁,女性67.5%),未根除组共116例(平均年龄56.2岁,女性74.1%)。根治组发生骨质疏松179例(24.5%),未根治组发生骨质疏松40例(34.5%)。骨质疏松症的重要危险因素包括女性(危险比[HR], 3.12; 95%可信区间[CI], 1.93至5.05)。结论:HP根除可作为预防骨质疏松症发展的干预措施,特别是在女性受试者中(ClinicalTrials.gov: NCT06818591)。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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