Malignant transformation of oral lichen planus after 6 years: a case report.

Q3 Medicine
General dentistry Pub Date : 2025-09-01
Patrícia Peres Iucif Pereira, Amanda Bandeira Almeida, João Adolfo Costa Hanneman, Eduardo Pereira Guimarães, Henrique Carvalho Petean, Daiana Moreira Mendes Rozendo, Alessandro Antônio Pereira
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引用次数: 0

Abstract

Lichen planus (LP) is a chronic or recurrent autoimmune mucocutaneous inflammatory disease. The etiology is uncertain, and it is considered to originate from a multifactorial process. A diagnosis can be made clinically if the disease presents with classic patterns of oral or skin lesions; if these patterns are absent, a biopsy is necessary to establish a diagnosis. Although the World Health Organization has classified oral LP (OLP) as an oral potentially malignant disorder, there is controversy in the literature. Malignancy usually occurs around 60 years of age, with a slight predilection for women. The objective of this case report is to describe a possible occurrence of this process. A 53-year-old woman who sought treatment for oral lesions in 2018 was diagnosed with OLP with epithelial dysplasia and underwent standard treatment with a topical corticosteroid. After ceasing to attend follow-up examinations, the patient continued periodontal treatment with different providers. In 2024, she developed a lesion on the maxillary right alveolar ridge that led to tooth loss in the region. A biopsy was performed, and histopathologic evaluation of the specimen led to a diagnosis of squamous cell carcinoma. There are several differential diagnoses for the clinical forms of OLP, in addition to the possibility of manifestation of concomitant pathoses, and the final diagnosis must reflect a combination of clinical and histopathologic examinations. Patients should be advised about the importance of returning for follow-up appointments, as malignant transformation of OLP may occur.

口腔扁平苔藓6年后恶性转化1例。
扁平苔藓(LP)是一种慢性或复发性自身免疫性粘膜皮肤炎症性疾病。病因不确定,它被认为起源于一个多因素过程。如果疾病表现为典型的口腔或皮肤病变,则可进行临床诊断;如果没有这些特征,则需要进行活检以确定诊断。虽然世界卫生组织将口腔LP (OLP)归类为口腔潜在恶性疾病,但文献中存在争议。恶性肿瘤通常发生在60岁左右,对女性有轻微的偏爱。本病例报告的目的是描述这一过程可能发生的情况。2018年,一名53岁的女性因口腔病变寻求治疗,被诊断为OLP伴上皮发育不良,并接受了局部皮质类固醇的标准治疗。在停止接受随访检查后,患者继续接受不同提供者的牙周治疗。2024年,她在上颌右牙槽嵴出现病变,导致该区域牙齿脱落。进行了活检,标本的组织病理学评估导致鳞状细胞癌的诊断。OLP的临床形式有几种鉴别诊断,除了可能表现为伴随的疾病,最终的诊断必须反映临床和组织病理学检查的结合。应告知患者返回随访预约的重要性,因为OLP可能发生恶性转化。
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来源期刊
General dentistry
General dentistry Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
134
期刊介绍: General Dentistry is the premier peer-reviewed journal of the Academy of General Dentistry (AGD). Published bi-monthly, General Dentistry presents research and clinical findings to support the full range of procedures that general dentists perform on a regular basis.
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