How Can We Reduce Cardiovascular Risk in Women and Improve Risk Stratification?

IF 5.2 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2025-08-19 DOI:10.1007/s11883-025-01332-9

Fabiana Hanna Rached, Viviane Zorzanelli Rocha, Thales Fraga Ferreira da Silva, Francesca Maria DiMuro, Roxana Mehran, Lucas Lage Marinho

{"title":"How Can We Reduce Cardiovascular Risk in Women and Improve Risk Stratification?","authors":"Fabiana Hanna Rached, Viviane Zorzanelli Rocha, Thales Fraga Ferreira da Silva, Francesca Maria DiMuro, Roxana Mehran, Lucas Lage Marinho","doi":"10.1007/s11883-025-01332-9","DOIUrl":null,"url":null,"abstract":"Purpose of review: To explore sex-specific dimensions of cardiovascular disease (CVD) by addressing key questions: (1) What is the true burden of CVD in women, and how does it compare with that in men across diverse populations? (2) Do risk factors for CVD differ between sexes in prevalence, biological impact, and prognostic significance? (3) Should we adopt sex-specific cardiovascular risk stratification tools to improve diagnostic precision in women? (4) Is there a need for earlier or more aggressive preventive strategies in women, particularly for those with sex-specific or predominant risk factors?Recent findings: CVD remains the leading cause of morbidity and mortality among women worldwide. Despite advances in care, significant sex-based disparities persist in awareness, diagnosis, risk stratification, and treatment. Women often present with distinct biological and psychosocial risk factors that are underrecognized in standard assessments. Emerging data support the development of sex-specific tools and earlier interventions tailored to these differences. This review highlights the need for a more nuanced, sex-sensitive approach to CVD prevention and management. By reevaluating traditional risk frameworks and incorporating female-specific and underrecognized contributors, there is potential to improve outcomes and close the persistent care gap for women.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"82"},"PeriodicalIF":5.2000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Atherosclerosis Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11883-025-01332-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: To explore sex-specific dimensions of cardiovascular disease (CVD) by addressing key questions: (1) What is the true burden of CVD in women, and how does it compare with that in men across diverse populations? (2) Do risk factors for CVD differ between sexes in prevalence, biological impact, and prognostic significance? (3) Should we adopt sex-specific cardiovascular risk stratification tools to improve diagnostic precision in women? (4) Is there a need for earlier or more aggressive preventive strategies in women, particularly for those with sex-specific or predominant risk factors?

Recent findings: CVD remains the leading cause of morbidity and mortality among women worldwide. Despite advances in care, significant sex-based disparities persist in awareness, diagnosis, risk stratification, and treatment. Women often present with distinct biological and psychosocial risk factors that are underrecognized in standard assessments. Emerging data support the development of sex-specific tools and earlier interventions tailored to these differences. This review highlights the need for a more nuanced, sex-sensitive approach to CVD prevention and management. By reevaluating traditional risk frameworks and incorporating female-specific and underrecognized contributors, there is potential to improve outcomes and close the persistent care gap for women.

查看原文本刊更多论文

如何降低女性心血管风险并改善风险分层？

综述的目的：通过解决以下关键问题，探讨心血管疾病（CVD）的性别特异性维度：(1)在不同人群中，女性的真正负担是什么，与男性的比较如何？(2)心血管疾病的危险因素在患病率、生物学影响和预后意义上是否存在性别差异？(3)是否应该采用基于性别的心血管风险分层工具来提高女性的诊断准确率？(4)是否需要对妇女采取更早或更积极的预防策略，特别是对那些具有特定性别或主要危险因素的妇女？最近发现：心血管疾病仍然是全世界妇女发病和死亡的主要原因。尽管在护理方面取得了进步，但在认识、诊断、风险分层和治疗方面仍然存在显著的性别差异。妇女往往表现出明显的生物和社会心理风险因素，而这些因素在标准评估中未得到充分认识。新出现的数据支持开发针对这些差异的针对性别的工具和早期干预措施。这篇综述强调了对心血管疾病预防和管理需要更细致、性别敏感的方法。通过重新评估传统的风险框架并纳入女性特有的和未被充分认识的贡献者，有可能改善结果并缩小妇女持续存在的护理差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.