Beyond the CBC: Can Novel Markers Predict Recurrence in Chronic Rhinosinusitis With Nasal Polyposis?

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-08-17 DOI:10.1111/coa.70024

Hasan Canakci, Hasmet Yazici, Salih Yayman, Kamil Gokce Tulaci, Erhan Arslan, Omer Hizli

{"title":"Beyond the CBC: Can Novel Markers Predict Recurrence in Chronic Rhinosinusitis With Nasal Polyposis?","authors":"Hasan Canakci, Hasmet Yazici, Salih Yayman, Kamil Gokce Tulaci, Erhan Arslan, Omer Hizli","doi":"10.1111/coa.70024","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>This study aimed to investigate the potential prognostic value of eosinophil count, eosinophil-monocyte ratio (EMR), total IgE, systemic immune-inflammatory index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and the presence of asthma and acetylsalicylic acid (ASA) sensitivity in predicting postoperative recurrence in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Patients with CRSwNP were divided into two groups based on recurrence within 3 years postoperatively: Group 1 (non-recurrent) included patients with no signs of recurrence, and Group 2 (recurrent) included those with endoscopic evidence of recurrence. A control group of age- and gender-matched healthy individuals without any history of inflammation and with normal nasal endoscopy findings was also included. Eosinophil, EMR, total IgE, NLR, PLR, SII, SIRI, and the presence of asthma and ASA sensitivity were compared among the groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The recurrent NP group had significantly higher median total IgE and PLR compared to the non-recurrent group (<i>p</i> = 0.036). Compared to controls, the recurrent NP group had significantly elevated eosinophil, EMR, SII, and SIRI levels (<i>p</i> < 0.001, <i>p</i> = 0.022, and <i>p</i> = 0.038, respectively). No significant differences in PLR, SII, or SIRI were found between the non-recurrent and control groups (<i>p</i> = 1). Multivariate logistic regression identified asthma as an independent predictor of recurrence.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>EMR, SII, and SIRI may serve as valuable biomarkers in CRSwNP. Their elevated levels in recurrent cases support their potential role in predicting postoperative recurrence.</p>\n </section>\n </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 6","pages":"1096-1102"},"PeriodicalIF":1.5000,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/coa.70024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

This study aimed to investigate the potential prognostic value of eosinophil count, eosinophil-monocyte ratio (EMR), total IgE, systemic immune-inflammatory index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and the presence of asthma and acetylsalicylic acid (ASA) sensitivity in predicting postoperative recurrence in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).

Methods

Patients with CRSwNP were divided into two groups based on recurrence within 3 years postoperatively: Group 1 (non-recurrent) included patients with no signs of recurrence, and Group 2 (recurrent) included those with endoscopic evidence of recurrence. A control group of age- and gender-matched healthy individuals without any history of inflammation and with normal nasal endoscopy findings was also included. Eosinophil, EMR, total IgE, NLR, PLR, SII, SIRI, and the presence of asthma and ASA sensitivity were compared among the groups.

Results

The recurrent NP group had significantly higher median total IgE and PLR compared to the non-recurrent group (p = 0.036). Compared to controls, the recurrent NP group had significantly elevated eosinophil, EMR, SII, and SIRI levels (p < 0.001, p = 0.022, and p = 0.038, respectively). No significant differences in PLR, SII, or SIRI were found between the non-recurrent and control groups (p = 1). Multivariate logistic regression identified asthma as an independent predictor of recurrence.

Conclusion

EMR, SII, and SIRI may serve as valuable biomarkers in CRSwNP. Their elevated levels in recurrent cases support their potential role in predicting postoperative recurrence.

Abstract Image

查看原文本刊更多论文

超越CBC：新的标志物能预测慢性鼻窦炎伴鼻息肉的复发吗？

摘要：本研究旨在探讨嗜酸性粒细胞计数、嗜酸性粒细胞-单核细胞比（EMR）、总IgE、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）、中性粒细胞-淋巴细胞比（NLR）、血小板-淋巴细胞比（PLR）、哮喘和乙酰水杨酸（ASA）敏感性对慢性鼻窦炎合并鼻息肉（CRSwNP）患者术后复发的潜在预后价值。方法：将CRSwNP患者根据术后3年内的复发情况分为两组：1组（非复发）包括无复发迹象的患者，2组（复发）包括内镜下有复发证据的患者。对照组包括年龄和性别匹配的健康个体，没有任何炎症史，鼻内窥镜检查结果正常。比较各组间嗜酸性粒细胞、EMR、总IgE、NLR、PLR、SII、SIRI、哮喘及ASA敏感性。结果：NP复发组总IgE和PLR中位数明显高于非复发组（p = 0.036）。与对照组相比，复发性NP组嗜酸性粒细胞、EMR、SII和SIRI水平显著升高(p结论：EMR、SII和SIRI可能是CRSwNP中有价值的生物标志物。它们在复发病例中的升高水平支持了它们在预测术后复发中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.