Construction of a Ru(phen)2L-Asp/ZnO@Zn(l-tar)(4,4′-bipy)/FTO-based electrochemiluminescence chiral sensor and its application for simultaneous recognition of menthol and penicillamine enantiomers†

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2025-08-15 DOI:10.1039/D5AY00528K

Rui Kuang and Bing Yang

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Abstract

Ru(phen)₃Cl₂ exhibits good ECL response, but it lacks chiral sites and cannot effectively recognize chiral compounds. In this study, a uniform array of ZnO nanorods was synthesized via electrochemical deposition, which served as the zinc source for the subsequent in situ growth of chiral Zn(L-tar)(4,4′-bipy) MOF shells on the nanorod surfaces through a solvothermal method. The Ru(phen)₂L-Asp complex was then immobilized onto the ZnO@Zn(4,4′-bipy)(L-tar)/FTO substrate to construct a novel Ru(phen)₂L-Asp/ZnO@Zn(4,4′-bipy)(L-tar)/FTO electrochemiluminescence (ECL) chiral sensor. This dual-recognition ECL sensor demonstrated excellent capability for simultaneous detection of Pen and Men enantiomers with remarkable quantitative discrimination performance. This strategy represents a significant advancement for developing high-throughput ECL chiral sensing systems.

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Ru(phen)2L-Asp/ZnO@Zn(L-tar)(4,4′-bipy)/ fto电化学发光手性传感器的构建及其在薄荷醇和青霉胺对映体同时识别中的应用

Ru(phen)3Cl2具有良好的ECL响应，但缺乏手性位点，不能有效识别手性化合物。本研究通过电化学沉积法制备了均匀排列的ZnO纳米棒，作为锌源，通过溶剂热法在纳米棒表面原位生长手性Zn(L-tar)(4,4′-bipy) MOF壳。将Ru(phen)2L-Asp配合物固定在ZnO@Zn(4,4′-bipy)(L-tar)/FTO底物上，构建新型Ru(phen)2L-Asp/ZnO@Zn(4,4′-bipy)(L-tar)/FTO电化学发光（ECL）手性传感器。该双识别ECL传感器具有良好的同时检测Pen和Men对映体的能力，并具有显著的定量鉴别性能。该策略代表了开发高通量ECL手性传感系统的重大进步。

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