{"title":"Exploring Europium Complex With Aggregation Induced Emission Properties for Immune Fluorescence Test Strips Applications","authors":"Mengjiao Xu, Jinghan Wang, Zixuan Liao, Jiqiang Liu, Hao Yi, Hongxia Hao, Feng Li, Siyi Xu, Fufeng Liu, Yonglin Peng, Shenglan Wang, Xiaodong Cao, Pengfei Zhang","doi":"10.1002/bio.70289","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Highly luminescent nanospheres have been demonstrated to enhance the sensitivity of lateral flow immunoassay (LFIA) due to their loading of numerous luminescent dyes. Herein, aggregation-induced emission (AIE) luminogens (AIEgens)-embedded nanospheres (AIENPs) with red-emissive AIE-active europium complexes were developed as signal amplification probes for LFIA for rapid and point-of-care detection of COVID-19 biomarkers, nasopharyngeal carcinoma biomarkers, and methamphetamine. Compared with the colloidal gold-based rapid and point-of-care detection approach, the AIENPs-based approach showed more than 10 times sensitivity to the target proteins and small molecules, highlighting its significant potential for pathogen- or cancer-related diseases early detection and screening, as well as its applicability in public safety monitoring.</p>\n </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 8","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Luminescence","FirstCategoryId":"92","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/bio.70289","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Highly luminescent nanospheres have been demonstrated to enhance the sensitivity of lateral flow immunoassay (LFIA) due to their loading of numerous luminescent dyes. Herein, aggregation-induced emission (AIE) luminogens (AIEgens)-embedded nanospheres (AIENPs) with red-emissive AIE-active europium complexes were developed as signal amplification probes for LFIA for rapid and point-of-care detection of COVID-19 biomarkers, nasopharyngeal carcinoma biomarkers, and methamphetamine. Compared with the colloidal gold-based rapid and point-of-care detection approach, the AIENPs-based approach showed more than 10 times sensitivity to the target proteins and small molecules, highlighting its significant potential for pathogen- or cancer-related diseases early detection and screening, as well as its applicability in public safety monitoring.
期刊介绍：
Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry.
Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.
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