The Relationship of Alzheimer's Disease and Related Dementias Blood-Based Biomarkers and Informant-Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia

IF 2.8 3区医学 Q2 GERIATRICS & GERONTOLOGY

International Journal of Geriatric Psychiatry Pub Date : 2025-08-19 DOI:10.1002/gps.70140

Julia R. Bacci, Marc D. Rudolph, Suzanne Craft, James R. Bateman, Samuel N. Lockhart, Michelle M. Mielke

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引用次数: 0

Abstract

Objectives

In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs. child vs. other) modified that association.

Methods

This study included 430 participants with a cognitively unimpaired or mild cognitive impairment consensus diagnosis from the Wake Forest Alzheimer's Disease Research Center Clinical Core cohort. Informants reported NPS using the Neuropsychiatric Inventory Questionnaire. AD/ADRD BBMs included the Aβ42/40 ratio, p-tau181, p-tau217, NfL, and GFAP. Generalized linear models were used to examine the associations between AD/ADRD BBMs and NPS. Secondary models adjusted for age, sex, education, race, and cognitive status. Tertiary models adjusted for covariates in secondary models, as well as informant type. Interactions between informant type and AD/ADRD BBMs were examined.

Results

Higher p-tau217 was associated with higher NPS in both unadjusted models and models adjusted for demographics and cognitive status. This association was attenuated and no longer statistically significant after additionally adjusting for informant type. Significant interactions of informant type and p-tau181 or p-tau217 on NPS were demonstrated, where p-tau181 or p-tau217 were more strongly associated with NPS reported by children compared to spouses.

Conclusions

Informant type modified the association between AD/ADRD BBMs and NPS, with stronger associations observed when symptoms were reported by child informants compared to spouse informants. These findings have important implications for earlier detection of individuals with AD/ADRD pathologies.

Abstract Image

查看原文本刊更多论文

在无痴呆的老年人中，阿尔茨海默病和相关痴呆的血液生物标志物和举报人报告的神经精神症状的关系因举报人类型而异

在一个社区居住的老年人样本中，我们检查了阿尔茨海默病和相关痴呆（AD/ADRD）血液生物标志物（BBMs）和神经精神症状（NPS）的关联，以及信息提供者类型（即配偶、子女和其他）是否改变了这种关联。方法：本研究纳入了来自维克森林阿尔茨海默病研究中心临床核心队列的430名认知未受损或轻度认知障碍一致诊断的参与者。被调查者使用神经精神量表来报告NPS。AD/ADRD BBMs包括a - β42/40比值、p-tau181、p-tau217、NfL和GFAP。采用广义线性模型研究AD/ADRD BBMs与NPS之间的关系。二级模型根据年龄、性别、教育程度、种族和认知状况进行调整。三级模型调整了二级模型中的协变量，以及信息提供者类型。研究了举报人类型与AD/ADRD BBMs之间的相互作用。结果在未经调整的模型和根据人口统计学和认知状况调整的模型中，p-tau217较高与较高的NPS相关。在进一步调整线人类型后，这种关联减弱，不再具有统计学意义。研究表明，信息者类型和p-tau181或p-tau217对NPS有显著的相互作用，其中p-tau181或p-tau217与子女报告的NPS的相关性比配偶更强。结论：举报人类型改变了AD/ADRD脑卒中与NPS之间的关系，与配偶举报人相比，儿童举报人报告症状的相关性更强。这些发现对早期发现AD/ADRD患者具有重要意义。

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来源期刊

International Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

6.10

自引率

2.50%

发文量

168

审稿时长

4-8 weeks

期刊介绍： The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.