Whole Brain Spectral Power Differences During Infancy Following Antenatal SARS-CoV-2 and Zika Virus Exposure: Findings From Cohorts in Boston, Massachusetts and San Juan, Puerto Rico

IF 1.6 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-08-19 DOI:10.1002/jdn.70047

Viviane Valdes, Dashiell D. Sacks, Jennifer Near, Adriana S. Méndez Leal, Andrea G. Edlow, Carmen D. Zorrilla, Charles A. Nelson

{"title":"Whole Brain Spectral Power Differences During Infancy Following Antenatal SARS-CoV-2 and Zika Virus Exposure: Findings From Cohorts in Boston, Massachusetts and San Juan, Puerto Rico","authors":"Viviane Valdes, Dashiell D. Sacks, Jennifer Near, Adriana S. Méndez Leal, Andrea G. Edlow, Carmen D. Zorrilla, Charles A. Nelson","doi":"10.1002/jdn.70047","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Viral exposure during pregnancy is associated with adverse outcomes in offspring. Given the increasing frequency of viral outbreaks both locally and globally, the current study sought to examine the impact of antenatal exposure to Zika virus (ZIKV) and SARS-CoV-2 on infant neurophysiological development during the first year of life.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Families were recruited from two cohorts, one in San Juan, Puerto Rico (ZIKV) and one in Boston, Massachusetts (SARS-CoV-2). For the ZIKV cohort, infants were assessed cross-sectionally between 3 to 12 months of age. For SARS-CoV-2, infants were assessed longitudinally at 3, 6, 9 and 12 months. Electroencephalography (EEG) was used to compare absolute power during a resting state task across the whole brain (by spectral band) between infants with antenatal viral exposure and nonexposed infants. Data were analysed using generalized linear models (GLMs) and multilevel mixed effects models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In the ZIKV cohort, age-by-exposure interactions were observed for delta (<i>p</i> = 0.027) and theta power (<i>p</i> = 0.009), where exposed infants demonstrated decreasing power with age, while nonexposed infants demonstrated increasing power with age from 3 to 12 months. In the SARS-CoV-2 cohort, antenatally exposed children had lower levels of beta (<i>p</i> = 0.022) and gamma power (<i>p</i> = 0.044) overall from 3 to 12 months. Significant recovery was observed in trajectories for beta power by 12 months.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ZIKV exposure during pregnancy was associated with reductions in low-frequency EEG power, which may be indicative of disruptions in early brain maturation. SARS-CoV-2 exposure was associated with reductions in higher-frequency power, suggesting potential impairments on sensorimotor and cognitive integration. Increases in beta power by 12 months in the SARS-CoV-2 cohort indicate some recovery, although potential compounding and sleeper effects from early disruptions are possible.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 5","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70047","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Viral exposure during pregnancy is associated with adverse outcomes in offspring. Given the increasing frequency of viral outbreaks both locally and globally, the current study sought to examine the impact of antenatal exposure to Zika virus (ZIKV) and SARS-CoV-2 on infant neurophysiological development during the first year of life.

Methods

Families were recruited from two cohorts, one in San Juan, Puerto Rico (ZIKV) and one in Boston, Massachusetts (SARS-CoV-2). For the ZIKV cohort, infants were assessed cross-sectionally between 3 to 12 months of age. For SARS-CoV-2, infants were assessed longitudinally at 3, 6, 9 and 12 months. Electroencephalography (EEG) was used to compare absolute power during a resting state task across the whole brain (by spectral band) between infants with antenatal viral exposure and nonexposed infants. Data were analysed using generalized linear models (GLMs) and multilevel mixed effects models.

Results

In the ZIKV cohort, age-by-exposure interactions were observed for delta (p = 0.027) and theta power (p = 0.009), where exposed infants demonstrated decreasing power with age, while nonexposed infants demonstrated increasing power with age from 3 to 12 months. In the SARS-CoV-2 cohort, antenatally exposed children had lower levels of beta (p = 0.022) and gamma power (p = 0.044) overall from 3 to 12 months. Significant recovery was observed in trajectories for beta power by 12 months.

Conclusion

ZIKV exposure during pregnancy was associated with reductions in low-frequency EEG power, which may be indicative of disruptions in early brain maturation. SARS-CoV-2 exposure was associated with reductions in higher-frequency power, suggesting potential impairments on sensorimotor and cognitive integration. Increases in beta power by 12 months in the SARS-CoV-2 cohort indicate some recovery, although potential compounding and sleeper effects from early disruptions are possible.

Abstract Image

查看原文本刊更多论文

产前暴露于SARS-CoV-2和寨卡病毒后婴儿全脑频谱功率差异：来自马萨诸塞州波士顿和波多黎各圣胡安的队列研究结果

背景：怀孕期间病毒暴露与后代的不良后果有关。鉴于当地和全球病毒爆发的频率日益增加，本研究旨在研究产前暴露于寨卡病毒（ZIKV）和SARS-CoV-2对婴儿出生后第一年神经生理发育的影响。方法从波多黎各圣胡安（ZIKV）和马萨诸塞州波士顿（SARS-CoV-2）两个队列中招募家庭。在ZIKV队列中，对3至12个月大的婴儿进行横断面评估。对于SARS-CoV-2，在3、6、9和12个月时对婴儿进行纵向评估。使用脑电图（EEG）来比较在静息状态任务中，产前病毒暴露的婴儿和未暴露的婴儿的全脑绝对功率（通过频谱带）。数据分析采用广义线性模型（GLMs）和多级混合效应模型。结果在ZIKV队列中，观察到年龄暴露相互作用的δ (p = 0.027)和θ功率（p = 0.009），暴露婴儿的功率随着年龄的增长而下降，而未暴露婴儿的功率随着年龄的增长而增加。在SARS-CoV-2队列中，产前暴露的儿童在3至12个月的总体β (p = 0.022)和γ功率（p = 0.044）水平较低。在12个月的时间里，观察到β功率轨迹的显著恢复。结论妊娠期寨卡病毒暴露与低频脑电图功率降低有关，这可能预示着早期脑成熟的中断。SARS-CoV-2暴露与高频功率降低有关，这表明感觉运动和认知整合可能受到损害。在SARS-CoV-2队列中，β功率增加了12个月，表明有所恢复，尽管早期中断可能产生潜在的复合效应和睡眠效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.