Advances in the Study of Pyroptosis in Dermatological Disorders

IF 3.1 3区医学 Q1 DERMATOLOGY

Experimental Dermatology Pub Date : 2025-08-19 DOI:10.1111/exd.70148

Shenghao Xue, Yumeng Lin, Lusheng Liu, Ke Wang, Qian Guo, Ruyi Zhang, Kaisheng Zeng, Jin Jiang, Zhinan Deng, Lan Yuan, Zhongyu Han, Xiaohong Zuo

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Abstract

Pyroptosis is a proinflammatory procedural cell die-off characterised by the forming of membrane pores that are mediated by a series of aerogelin proteins. Pyroptosis occurs by caspase-1 dependent typical signalling pathways, caspase-4/5/11 dependent atypical signalling pathways, and other signalling pathways (GSDME, GSDMD, GSDMA, GSDMB and GSDMC mediated signalling pathways). Pyroptosis may assist in the elimination of the pathogen as a type of mechanism of host defence, but pyroptosis-induced inflammation can lead to dysfunction and organ damage, exacerbating the pathology of the disease. Several existing researches have suggested that pyroptosis is implicated in the etiopathogenesis of a majority of dermatologic disorders, including systemic lupus erythematosus (SLE), psoriasis (PA), atopic dermatitis (AD), systemic sclerosis (SSc), vitiligo and chronic spontaneous urticaria (CSU). In this review, we examine the available literature, focusing on the mechanistic aspects of pyroptosis and the involvement of pyroptosis in the six dermatologic disorders mentioned above, to aid in further research in the future.

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皮肤疾病热下垂的研究进展

焦亡是一种促炎程序性细胞死亡，其特征是由一系列气凝胶蛋白介导的膜孔的形成。通过caspase-1依赖的典型信号通路、caspase-4/5/11依赖的非典型信号通路以及其他信号通路（GSDME、GSDMD、GSDMA、GSDMB和GSDMC介导的信号通路）发生焦亡。作为宿主防御的一种机制，热亡可能有助于消除病原体，但热亡诱导的炎症可导致功能障碍和器官损伤，加剧疾病的病理。现有的一些研究表明，热下垂与大多数皮肤疾病的发病机制有关，包括系统性红斑狼疮（SLE）、牛皮癣（PA）、特应性皮炎（AD）、系统性硬化症（SSc）、白癜风和慢性自发性荨麻疹（CSU）。在这篇综述中，我们检查了现有的文献，重点关注焦亡的机制方面以及焦亡在上述六种皮肤病中的参与，以帮助未来进一步的研究。

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来源期刊

Experimental Dermatology 医学-皮肤病学

CiteScore

6.70

自引率

5.60%

发文量

201

审稿时长

2 months

期刊介绍： Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.