One-Pot, for the Green Preparation of Benzimidazoles and 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by In2O3 NPs/Glycerol

IF 4.9 3区化学 Q2 POLYMER SCIENCE

Journal of Inorganic and Organometallic Polymers and Materials Pub Date : 2025-01-24 DOI:10.1007/s10904-025-03604-y

Fadhil Faez Sead, Vicky Jain, Anjan Kumar, Subbulakshmi Ganesan, Aman Shankhyan, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas

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Abstract

Benzimidazoles and 2,3-dihydroquinazolin-4(1H)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In₂O₃ NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.

Graphical Abstract

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一锅绿色合成苯并咪唑和2,3-二氢喹唑啉-4(1H)-的研究

苯并咪唑类和2,3-二氢喹唑啉-4(1H)-一类具有开发新型治疗剂的潜力，在药物化学领域受到广泛关注。本研究提出了一种以氧化铟纳米颗粒（In2O3 NPs）为催化剂的一锅法合成这些化合物的创新方法，该方法在七个循环中显示出一致的效率和可重复使用性。甘油是一种环境友好型溶剂，在温和条件下使用。研究表明，苯环上不同的取代基对反应效率没有影响，产物收率较高。氧化铟纳米颗粒优于以前的催化剂，通常导致较低的收率和较长的反应时间，同时较少重复使用。采用FT-IR、BET、TEM、XRD、TGA等技术对催化剂进行了表征，证实了多次使用后催化剂的保留活性。图形抽象

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来源期刊

Journal of Inorganic and Organometallic Polymers and Materials 化学-高分子科学

CiteScore

8.30

自引率

7.50%

发文量

335

审稿时长

1.8 months

期刊介绍： Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.