Conducting multicenter simulation-based experimental research: lessons drawn from the Quality CPR European project

IF 2.4 Q3 CRITICAL CARE MEDICINE
Carla Sa-Couto , Christoffer Ericsson , Marc Lazarovici
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引用次数: 0

Abstract

Multicenter research designs are widely recognized for enhancing the generalizability and real-world applicability of findings across diverse healthcare settings. However, conducting experimental studies across international sites presents substantial methodological, logistical, and operational challenges.
Quality CPR was a European multicenter simulation-based experimental study conducted across academic institutions in Portugal, Germany, and Finland. Using a randomized crossover design, the study investigated factors influencing chest compression quality and rescuer fatigue during simulated cardiopulmonary resuscitation.
Rather than serving as a methodological guide, this paper reflects on the practical experience of designing and implementing the Quality CPR study, highlighting twelve key lessons across the research lifecycle—planning, development, execution, and dissemination. These include collaborative protocol design, the development of a practical researcher guide to ensure cross-site harmonization, active support and real-time data monitoring during execution, and integrated dissemination strategies throughout the project lifecycle.
By documenting the enablers of success, this paper provides a practical reference for researchers planning similar international, multicenter studies. The insights offered aim to support the growing community of healthcare researchers engaged in cross-institutional initiatives.
开展基于多中心模拟的实验研究:来自Quality CPR欧洲项目的经验教训
多中心研究设计被广泛认可,因为它增强了研究结果在不同医疗保健环境中的普遍性和现实世界的适用性。然而,在国际站点进行实验研究提出了大量的方法、后勤和操作方面的挑战。高质量CPR是一项欧洲多中心模拟实验研究,在葡萄牙、德国和芬兰的学术机构中进行。采用随机交叉设计,研究模拟心肺复苏过程中影响胸按压质量和急救人员疲劳的因素。本文反思了设计和实施高质量CPR研究的实践经验,而不是作为方法指南,强调了整个研究生命周期的12个关键经验——计划、开发、执行和传播。这些包括协作协议设计,开发实用的研究人员指南,以确保跨站点的协调,执行过程中的主动支持和实时数据监控,以及整个项目生命周期的综合传播策略。通过记录成功的促成因素,本文为研究人员计划类似的国际,多中心研究提供了实用参考。提供的见解旨在支持越来越多的从事跨机构倡议的医疗保健研究人员。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Resuscitation plus
Resuscitation plus Critical Care and Intensive Care Medicine, Emergency Medicine
CiteScore
3.00
自引率
0.00%
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0
审稿时长
52 days
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