Mechanisms of pyroptosis in vitiligo

IF 2.5 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-08-10 DOI:10.1016/j.tice.2025.103081

Yingying Geng, Pengfei Huang, Tingting Cui

引用次数: 0

Abstract

Vitiligo is a common depigmentation disorder characterized by the loss of skin pigmentation, resulting in white patches on the skin. The pathogenesis of vitiligo involves complex interactions between genetic, immunological and environmental factors. Recent studies have implicated pyroptosis, a form of programmed cell death, in the development and progression of vitiligo. Pyroptosis is characterized by the activation of inflammatory caspases, such as caspase-1, leading to cell lysis and the release of inflammatory cytokines. This process has been linked to the melanocytes and other cells within local microenvironment, as well as immune response observed in vitiligo, This review explores the mechanisms underlying pyroptosis and its implications for the physiological alterations in melanocytes and keratinocytes during vitiligo pathogenesis. Furthermore, we also summaries the crosstalk between pyroptosis and other pathogenic mechanisms in vitiligo. These findings not only enhance our understanding of melanocyte death but also suggest novel therapeutic targets for vitiligo.

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白癜风的焦亡机制

白癜风是一种常见的色素沉着障碍，其特征是皮肤色素沉着的丧失，导致皮肤上出现白色斑块。白癜风的发病涉及遗传、免疫和环境因素的复杂相互作用。最近的研究暗示焦亡，一种程序性细胞死亡的形式，在白癜风的发展和进展。焦亡的特征是炎性半胱天冬酶（caspase-1）的激活，导致细胞裂解和炎性细胞因子的释放。这一过程与白癜风局部微环境中的黑素细胞和其他细胞以及免疫反应有关，本文就白癜风发病过程中黑素细胞和角化细胞的生理变化及其机制进行了探讨。此外，我们还总结了白癜风热亡与其他致病机制之间的相互作用。这些发现不仅提高了我们对黑素细胞死亡的认识，而且为白癜风的治疗提供了新的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.