Morpho-mechanical analysis of porcine growth plate tissue mechanics under torsional shear

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-08-12 DOI:10.1016/j.jmbbm.2025.107160

L. Hucke , G.Q. Teixeira , A. Seitz , A.J. Gámez , A. Huß , N. Hammer , A. Wittek , J.A. Niestrawska

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引用次数: 0

Abstract

Torsional loading of the growth plate occurs in daily activities and sports and is associated with growth plate fractures. This study aimed to investigate the microstructural and mechanical properties of growth plate tissue under torsional loading, focusing on variations across individuals, growth plate types, and anatomical locations.

A total of 140 samples from three distinct growth plates in five porcine subjects were subjected to cyclic torsion tests followed by ultimate failure testing. Additionally, histological analyses were performed using Movat's pentachrome staining to assess tissue structure.

Mechanical testing revealed significant differences in shear moduli across growth plate types; notably, the proximal femur exhibited a higher primary shear modulus compared to both the distal femur and proximal tibia. Correlation analyses showed a negative relationship between hypertrophic zone thickness and primary shear modulus (

ρ = - 0.47

at 0.5°/s,

p < 0.001

), as well as between cell column angle and secondary shear modulus (

ρ = - 0.43

at 0.5°/s,

p = 0.015

This study provides essential insights into the mechanical behavior of growth plates and how structural variations influence their response to loading, aiding in the development of more accurate computational models.

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扭转剪切作用下猪生长板组织力学的形态力学分析

生长板的扭转载荷发生在日常活动和运动中，并与生长板骨折有关。本研究旨在研究扭转载荷下生长板组织的微观结构和力学性能，重点研究个体、生长板类型和解剖位置的差异。从5只猪的3个不同生长板上取140个样品进行了循环扭转试验，然后进行了最终破坏试验。此外，使用Movat's五色染色进行组织学分析以评估组织结构。力学试验表明，不同类型生长板的剪切模量存在显著差异；值得注意的是，与股骨远端和胫骨近端相比，股骨近端表现出更高的初级剪切模量。相关分析显示，肥厚带厚度与初级剪切模量之间呈负相关（0.5°/s时ρ= - 0.47, p= 0.001），细胞柱角度与次级剪切模量之间呈负相关（0.5°/s时ρ= - 0.43, p=0.015）。这项研究为生长板的力学行为以及结构变化如何影响其对载荷的响应提供了重要的见解，有助于开发更准确的计算模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.