Biphasic mammary tumor in a cat: Case report

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-08-11 DOI:10.1016/j.rvsc.2025.105857

Adina-Mihaela Pîrvu , Elvira Gagniuc , Cătălin Micșa , Andrea Cappelleri , Elena Brigandì , Manuella Militaru

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Abstract

Feline mammary tumors (FMT) are the third most common neoplasm in older domestic cats. Among these, biphasic tumors (BT) are particularly rare. BT feature two distinct neoplastic cell populations, a carcinomatous component and a non-epithelial one. This paper describes the histological and immunohistochemical features of a biphasic mammary tumor in a 7-year-old Domestic Shorthair female cat. Histopathology identified two malignant cell populations: a tubular epithelial proliferation and a highly cellular and pleomorphic mesenchymal population. Immunohistochemistry (IHC) for pan-cytokeratin, cytokeratin 18, cytokeratin 14, and cytokeratins 5/6 labeled the epithelial component of the tumor. The mesenchymal population was diffusely positive for vimentin and α-SMA, occasionally positive for calponin, and negative for p63. Ki-67 index was higher in the epithelial cells (88.8 %) compared to the interstitial cells (22.9 %). Based on histological and immunohistochemical findings, a diagnosis of carcinosarcoma was made. This study highlights the importance of including mammary BT in the differentials of feline mammary neoplasms, despite their rarity.

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猫双相乳腺肿瘤1例

猫乳腺肿瘤（FMT）是老年家猫的第三大常见肿瘤。其中，双相肿瘤（BT）尤为罕见。BT具有两种不同的肿瘤细胞群，一种是癌成分，一种是非上皮成分。本文描述了7岁家短毛母猫双相乳腺肿瘤的组织学和免疫组织化学特征。组织病理学鉴定了两个恶性细胞群：一个小管上皮细胞增殖和一个高度细胞和多形性间充质细胞群。泛细胞角蛋白、细胞角蛋白18、细胞角蛋白14和细胞角蛋白5/6的免疫组化（IHC）标记了肿瘤的上皮成分。间充质细胞群中vimentin和α-SMA呈弥漫性阳性，钙钙蛋白偶有阳性，p63呈阴性。Ki-67指数在上皮细胞（88.8%）高于间质细胞（22.9%）。根据组织学和免疫组织化学检查结果，诊断为癌肉瘤。这项研究强调了包括乳腺BT在猫乳腺肿瘤差异中的重要性，尽管它们很罕见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.