Between enhancement and risk: A critical review of psychedelic microdosing

Abstract

Microdosing psychedelics, the regular use of low doses of LSD or psilocybin, have attracted growing public and scientific interest. This review synthesizes findings from 57 human studies on psychological and physiological outcomes in clinical and non-clinical populations. Reported benefits include improved mood, enhanced cognition, social functioning, and mental health, although findings are inconsistent and largely self-reported. Adverse effects such as anxiety, physical discomfort, and cognitive disruption are also frequently reported. Outcomes appear to be highly individual and shaped by user expectations, context, and baseline state. Notably, many experimental studies focus on the acute effects of single low doses, whereas observational studies reflect repeated use and generally report more benefits, while experimental trials tend to yield more null findings. Differences between observational and experimental findings highlight the need for rigorous, placebo-controlled research. While microdosing shows potential in some studies, current evidence remains inconclusive and warrants caution.