Assessing dose variability in PET/CT-based voxel dosimetry for Y-90 radioembolization

IF 2.6 3区工程技术 Q1 NUCLEAR SCIENCE & TECHNOLOGY

Nuclear Engineering and Technology Pub Date : 2025-08-20 DOI:10.1016/j.net.2025.103856

Sangseok Ha , Jieun Han , Seohan Kim , Dong-san Kang , Wonmo Sung

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引用次数: 0

Abstract

Purpose

This study aimed to evaluate the impact of calculation parameters on organ dose coefficients in image-based dosimetry for Yttrium-90 (Y-90) transarterial radioembolization (TARE).

Methods

Patient-specific dose coefficient maps were generated using PET/CT images from six hepatocellular carcinoma patients using TOPAS Monte Carlo simulations. To reduce spurious activity, PET values below varying thresholds (0, 50, and 100 kBq/mL) were excluded, and the effect of these thresholds on dose coefficients was assessed. The influence of CT Hounsfield unit conversion was examined by varying the number of materials from 1 to 24. The effects of dose calculation method, physics models, and voxel sizes on dose coefficients were systematically investigated.

Results

Spurious activity was the dominant factor influencing the variability of the dose coefficient. Adapting the activity threshold resulted in the mean difference of 38.8 (15.2 %), 3.3 (11.9 %), and 0.1 (6.5 %) Gy/GBq for the tumor, liver, and lungs. The mean difference of lung dose coefficient (1.1 Gy/GBq, 67.2 %) between single and 24 materials. The dose calculation method, physics model, and PET voxel size had a relatively small impact on variability.

Conclusions

This study systematically evaluated potential factors contributing variability of dose coefficient after Y-90 TARE, with spurious activity identified as a major factor.

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评估基于PET/ ct的体素剂量法用于Y-90放射栓塞的剂量变异性

目的探讨基于图像的经动脉放射栓塞（TARE）中钇-90 （Y-90）剂量测定中计算参数对器官剂量系数的影响。方法利用TOPAS蒙特卡罗模拟方法，对6例肝癌患者的PET/CT图像生成患者特异性剂量系数图。为了减少假活性，PET值低于不同阈值（0、50和100 kBq/mL）被排除，并评估这些阈值对剂量系数的影响。通过改变材料数量从1到24来检测CT霍斯菲尔德单位转换的影响。系统研究了剂量计算方法、物理模型和体素大小对剂量系数的影响。结果假活性是影响剂量系数变异性的主要因素。调整活动阈值导致肿瘤、肝脏和肺部的平均差异为38.8（15.2%）、3.3（11.9%）和0.1 (6.5%)Gy/GBq。单一材料与24种材料肺剂量系数的平均差异（1.1 Gy/GBq, 67.2%）。剂量计算方法、物理模型和PET体素大小对变异的影响相对较小。结论本研究系统地评估了Y-90 TARE后剂量系数变异性的潜在影响因素，其中假活性是主要影响因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Engineering and Technology 工程技术-核科学技术

CiteScore

4.80

自引率

7.40%

发文量

431

审稿时长

3.5 months

期刊介绍： Nuclear Engineering and Technology (NET), an international journal of the Korean Nuclear Society (KNS), publishes peer-reviewed papers on original research, ideas and developments in all areas of the field of nuclear science and technology. NET bimonthly publishes original articles, reviews, and technical notes. The journal is listed in the Science Citation Index Expanded (SCIE) of Thomson Reuters. NET covers all fields for peaceful utilization of nuclear energy and radiation as follows: 1) Reactor Physics 2) Thermal Hydraulics 3) Nuclear Safety 4) Nuclear I&C 5) Nuclear Physics, Fusion, and Laser Technology 6) Nuclear Fuel Cycle and Radioactive Waste Management 7) Nuclear Fuel and Reactor Materials 8) Radiation Application 9) Radiation Protection 10) Nuclear Structural Analysis and Plant Management & Maintenance 11) Nuclear Policy, Economics, and Human Resource Development