Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic applications

Intelligent Pharmacy Pub Date : 2025-08-01 DOI:10.1016/j.ipha.2024.09.005

Jyotiraditya Mall, Nazish Naseem, Md Faheem Haider, Md Azizur Rahman, Sara Khan, Sana Naaz Siddiqui

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引用次数: 0

Abstract

Recent advances in nanotechnology have enabled significant developments in health through innovative drug delivery systems. Nanostructured lipid carriers (NLCs) have emerged as a key technology in this field, offering enhanced drug stability, improved loading capacity, and reduced drug leakage compared to traditional solid lipid nanoparticles (SLNs). NLCs, such as ARM-NLC and PIO-loaded NLCs are specifically designed to optimize drug delivery and efficacy. Unlike other nanocarriers, NLCs provide controlled release and targeted delivery, making them highly effective for treating a range of diseases. Their applications include the treatment of skin cancer, Parkinson's disease, Alzheimer's disease, and breast cancer. The use of surface-engineered nanolayer coatings in NLCs has demonstrated significant improvements in targeting and delivering medications and bioactive substances to infection sites. Both in vitro and in vivo studies have shown promising results regarding the safety and efficacy of these NLC-based drug delivery systems.

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纳米结构脂质载体作为药物传递系统：与治疗应用的综合综述

纳米技术的最新进展通过创新的给药系统使卫生领域取得了重大发展。纳米结构脂质载体（nlc）已成为该领域的关键技术，与传统的固体脂质纳米颗粒（sln）相比，它具有更高的药物稳定性、更高的负载能力和更少的药物泄漏。nlc，如ARM-NLC和pio负载nlc是专门设计用于优化药物传递和疗效的。与其他纳米载体不同，NLCs提供可控释放和靶向递送，使其对治疗一系列疾病非常有效。它们的应用包括皮肤癌、帕金森病、阿尔茨海默病和乳腺癌的治疗。在nclc中使用表面工程纳米涂层已经证明了在靶向和向感染部位递送药物和生物活性物质方面的显著改进。体外和体内研究都显示了这些基于nlc的给药系统的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Intelligent Pharmacy

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