Multi-wavelength centrifugal processing enables 3D printing of functionally graded medical devices: Construction and validation of mechanically tunable orthodontic aligners

IF 11.1 1区 工程技术 Q1 ENGINEERING, MANUFACTURING
Xincheng Yin , Qian Zhang , Yuqi Li , Daxin Wu , Siyu Wang , Yanzhe Fu , Siyang Wei , Na Li , Xun Chen , Xiang Ding , Chao Wang , Yubo Fan , Jianmin Han , Jiebo Li
{"title":"Multi-wavelength centrifugal processing enables 3D printing of functionally graded medical devices: Construction and validation of mechanically tunable orthodontic aligners","authors":"Xincheng Yin ,&nbsp;Qian Zhang ,&nbsp;Yuqi Li ,&nbsp;Daxin Wu ,&nbsp;Siyu Wang ,&nbsp;Yanzhe Fu ,&nbsp;Siyang Wei ,&nbsp;Na Li ,&nbsp;Xun Chen ,&nbsp;Xiang Ding ,&nbsp;Chao Wang ,&nbsp;Yubo Fan ,&nbsp;Jianmin Han ,&nbsp;Jiebo Li","doi":"10.1016/j.addma.2025.104930","DOIUrl":null,"url":null,"abstract":"<div><div>Functionally Graded Materials (FGMs) have gained substantial attention in biomedical device development, particularly for creating functionally adaptive solutions. In recent years, grayscale vat photopolymerization 3D printing has emerged as a promising technology for FGMs fabrication owing to its advantages of high efficiency and precision. However, the residual unreacted monomers in grayscale printing components have brought a large amount of toxicity, becoming a bottleneck restricting their application in biomedical fields. This study proposes a multi-wavelength stepwise curing strategy that integrates wavelength-selective photoabsorber (PA) into the resin, using clear orthodontic aligners as a platform, to achieve a highly polymerized surface state while enabling gradient mechanical properties. Based on the integration of light field simulation and photopolymerization kinetics, a mathematical model was developed to predict the degree of conversion (DoC) distribution in multi-layer printing. The printed aligners demonstrated validated biocompatibility, with <em>in vitro</em> experiments showing that grayscale modulation effectively reduced orthodontic forces on non-targeted teeth while resisting stress relaxation during 7-day continuous monitoring. Furthermore, a centrifugation-based post processing method was developed to effectively eliminate surface layer steps and reduce bacterial adhesion. This process is compatible with the majority of current photopolymer resin systems and provides a technical framework for developing advanced functional medical devices.</div></div>","PeriodicalId":7172,"journal":{"name":"Additive manufacturing","volume":"110 ","pages":"Article 104930"},"PeriodicalIF":11.1000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Additive manufacturing","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214860425002945","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MANUFACTURING","Score":null,"Total":0}
引用次数: 0

Abstract

Functionally Graded Materials (FGMs) have gained substantial attention in biomedical device development, particularly for creating functionally adaptive solutions. In recent years, grayscale vat photopolymerization 3D printing has emerged as a promising technology for FGMs fabrication owing to its advantages of high efficiency and precision. However, the residual unreacted monomers in grayscale printing components have brought a large amount of toxicity, becoming a bottleneck restricting their application in biomedical fields. This study proposes a multi-wavelength stepwise curing strategy that integrates wavelength-selective photoabsorber (PA) into the resin, using clear orthodontic aligners as a platform, to achieve a highly polymerized surface state while enabling gradient mechanical properties. Based on the integration of light field simulation and photopolymerization kinetics, a mathematical model was developed to predict the degree of conversion (DoC) distribution in multi-layer printing. The printed aligners demonstrated validated biocompatibility, with in vitro experiments showing that grayscale modulation effectively reduced orthodontic forces on non-targeted teeth while resisting stress relaxation during 7-day continuous monitoring. Furthermore, a centrifugation-based post processing method was developed to effectively eliminate surface layer steps and reduce bacterial adhesion. This process is compatible with the majority of current photopolymer resin systems and provides a technical framework for developing advanced functional medical devices.
多波长离心加工使功能分级医疗设备的3D打印成为可能:机械可调正畸对准器的构建和验证
功能梯度材料(fgm)在生物医学设备开发中获得了大量关注,特别是在创建功能自适应解决方案方面。近年来,灰度还原釜光聚合3D打印以其高效率和高精度的优点成为一种很有前途的fgm制造技术。然而,灰度打印组件中残留的未反应单体带来了大量的毒性,成为制约其在生物医学领域应用的瓶颈。本研究提出了一种多波长逐步固化策略,该策略将波长选择性光吸收剂(PA)集成到树脂中,使用透明正畸对准器作为平台,以实现高度聚合的表面状态,同时实现梯度机械性能。在光场模拟和光聚合动力学相结合的基础上,建立了多层打印中转化度(DoC)分布的数学模型。打印的校准器显示出有效的生物相容性,体外实验表明,在连续7天的监测中,灰度调制有效地减少了非目标牙齿的正畸力,同时抵抗应力松弛。此外,开发了一种基于离心的后处理方法,可以有效地消除表层步骤并减少细菌粘附。该工艺与目前大多数光聚合物树脂系统兼容,并为开发先进的功能性医疗设备提供了技术框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Additive manufacturing
Additive manufacturing Materials Science-General Materials Science
CiteScore
19.80
自引率
12.70%
发文量
648
审稿时长
35 days
期刊介绍: Additive Manufacturing stands as a peer-reviewed journal dedicated to delivering high-quality research papers and reviews in the field of additive manufacturing, serving both academia and industry leaders. The journal's objective is to recognize the innovative essence of additive manufacturing and its diverse applications, providing a comprehensive overview of current developments and future prospects. The transformative potential of additive manufacturing technologies in product design and manufacturing is poised to disrupt traditional approaches. In response to this paradigm shift, a distinctive and comprehensive publication outlet was essential. Additive Manufacturing fulfills this need, offering a platform for engineers, materials scientists, and practitioners across academia and various industries to document and share innovations in these evolving technologies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信