Fahimeh Hamzavi, Mohammad Javad Karimi, Mahdi Bahadoran
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引用次数: 0
Abstract
Thermal ablation is a treatment modality for liver cancer that utilizes heat to destroy cancerous tissues. The numerical analysis of thermal ablation processes in liver tissue was studied using two different methods: microwave ablation (MWA) and radiofrequency ablation (RFA). The effectiveness of both methods and the thermal characteristics of tumor ablation, including temperature distribution, temporal variation in temperature, volume of ablation, and destruction of cancerous tissue, were investigated. MWA requires less time for complete ablation than RFA and can generate larger ablation zones. Additionally, a novel electrode-based design for RFA, we call it Norfolk pine electrode (NPE), which focuses on ablating large and spherical tumors, has been proposed and analyzed. To the best of our knowledge, the conventional RFA designs, which utilize the Christmas tree electrode and umbrella electrode, are effective in ablating tumors smaller than . However, they fail to completely eradicate spherical tumors. Our proposed NPE can fully ablate spherical tumors larger than 3 cm, demonstrating faster and more effective tissue ablation with higher necrosis rates than the conventional umbrella-shaped electrode designs. This NPE could be a promising and practical advancement in the realm of tumor treatment.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles