Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-08-07 DOI:10.1016/j.jpsychores.2025.112345

Kirsten Voorhies , Jess G. Fiedorowicz , Abebaw M. Yohannes , Gregory L. Kinney , Dawn L. DeMeo , Elizabeth A. Regan , James D. Crapo , Edwin K. Silverman , Christoph Lange , Karin F. Hoth , Sharon M. Lutz

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引用次数: 0

Abstract

Objective

Examine clinical and demographic variables associated with new onset depression and anxiety symptoms and assess moderation by sex in COPDGene, a cohort study of current and former smokers at risk for or with chronic obstructive pulmonary disease (COPD).

Methods

In the COPDGene study, 2653 adults had the hospital anxiety (HADS-A) and depression (HADS-D) scales available at phase 2 and 3, as well as clinical and demographic variables available at 2 and non-elevated HADS at phase 2. We defined new onset depression symptoms as HADS-D elevated at phase 3 (HADS-D ≥ 8) versus no new onset as HADS-D not elevated at either phase (HADS-D < 8). New onset anxiety symptoms were defined identically using HADS-A. We used logistic regression models among all participants and stratified by sex and assessed sex interactions for variables associated with the outcome for only one sex.

Results

Among males, COPD Assessment test (CAT) score was positively associated with new onset depression (β = 0.08, p = 1.9 × 10⁻⁵) and anxiety (β = 0.06, p = 1.4 × 10⁻³) symptoms. Among females, the modified Medical Research Council (mMRC) dyspnea was positively associated with new onset anxiety symptoms (β = 0.33, p = 1.4 × 10⁻³). We found sex by CAT score (β = −0.06, p = 0.02) and sex by mMRC dyspnea (β = 0.42, p = 5.1 × 10⁻³) interactions on new onset anxiety symptoms, and sex by CAT score interaction (β = −0.05, p = 0.04) on new onset depression symptoms.

Conclusions

These findings highlight the importance of understanding factors that increase risk for depression and anxiety among smokers at risk for or with COPD and are moderated by sex.

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在COPDGene研究中，与新发抑郁和焦虑症状相关的因素因性别而异

目的研究COPDGene中与新发抑郁和焦虑症状相关的临床和人口学变量，并评估性别调节，COPDGene是一项针对有慢性阻塞性肺疾病（COPD）风险或患有慢性阻塞性肺疾病（COPD）的当前和曾经吸烟者的队列研究。方法在COPDGene研究中，2653名成年人在2期和3期有医院焦虑（HADS- a）和抑郁（HADS- d）量表，在2期有临床和人口学变量，在2期没有升高的HADS。我们将新发抑郁症状定义为HADS-D在3期升高（HADS-D≥8），而无新发抑郁症状定义为HADS-D在两期均未升高（HADS-D < 8）。使用HADS-A对新发焦虑症状的定义相同。我们在所有参与者中使用了逻辑回归模型，并按性别分层，并评估了与一种性别的结果相关的变量的性别相互作用。结果男性COPD评估试验（CAT）评分与新发抑郁（β = 0.08, p = 1.9 × 10−5）和焦虑（β = 0.06, p = 1.4 × 10−3）症状呈正相关。在女性中，改良的医学研究委员会（mMRC）呼吸困难与新发焦虑症状呈正相关（β = 0.33, p = 1.4 × 10−3）。我们发现CAT评分的性别（β = - 0.06, p = 0.02）和mMRC呼吸困难的性别（β = 0.42, p = 5.1 × 10 - 3）对新发焦虑症状有交互作用，CAT评分的性别（β = - 0.05, p = 0.04）对新发抑郁症状有交互作用。结论：这些研究结果强调了了解在有COPD风险或患有COPD的吸烟者中增加抑郁和焦虑风险并受性别调节的因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.