Association of TGF-β1 with periodontitis patients in north Indian population

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-08-19 DOI:10.1016/j.jobcr.2025.08.021

Ruchi Pandey , Sumit Bhateja , Lipika Gopal , Ankita Chhabrani , Anju Rana , Puneet Batra

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引用次数: 0

Abstract

Introduction

Periodontitis is a complex disease caused by environmental and genetic factors. The course of periodontal destruction is influenced by local, ecological, and, predominantly, by genetic factors. Therefore, early detection of the disease through genomics and its course of destruction can be altered through genetic engineering, which can be a major breakthrough in the eradication of periodontitis.

Aim

The purpose of this study is to find the genetic association of TGF-β1 gene polymorphisms in causing periodontitis in the North Indian population.

Materials and methods

A total of 364 subjects were selected in the present study, and they were divided into two groups, viz. Healthy (Group A) and Periodontitis (Group B), with 182 subjects in each. The detailed case history was recorded, buccal swab samples were collected and stored in the sterile medium at 4 °C. Correlation studies on gene polymorphism with the disease occurrence were carried out by estimating allele frequency, Hardy-Weinberg equilibrium (HWE), and chi-square test (GenAlex package), and linkage disequilibrium and haplotype analysis (SHEsis).

Result

The gene TGF-β1 showed a high rate of polymorphism in the north Indian population. The TGF-β1 gene showed polymorphism in the studied SNP sites. Among them, −29C/T and −788 C/T could differentiate the healthy and generalized periodontitis group; however, the localized periodontitis group could not be differentiated with any of the SNP loci.

Conclusion

The gene TGF-β1 showed association with periodontitis in the North Indian Population.

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TGF-β1与印度北部人群牙周炎患者的关系

牙周炎是一种由环境和遗传因素引起的复杂疾病。牙周破坏的过程受局部、生态和遗传因素的影响。因此，通过基因组学早期发现疾病及其破坏过程可以通过基因工程改变，这可能是根除牙周炎的重大突破。目的探讨TGF-β1基因多态性与印度北部人群牙周炎发病的遗传关系。材料与方法本研究共选取364例受试者，分为健康组（A组）和牙周炎组（B组），每组182例。记录详细的病例史，收集口腔拭子样本，保存于无菌培养基中，温度4℃。通过估计等位基因频率、Hardy-Weinberg平衡（HWE）、卡方检验（GenAlex package）、连锁不平衡和单倍型分析（SHEsis）进行基因多态性与疾病发生的相关性研究。结果TGF-β1基因在印度北部人群中具有较高的多态性。TGF-β1基因在研究的SNP位点显示多态性。其中- 29C/T和- 788 C/T可区分健康组和广泛性牙周炎组；然而，局部牙周炎组不能与任何SNP位点区分。结论TGF-β1基因与印度北部人群牙周炎有关。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.