Comparative Roles of Hydrogels, Deep Eutectic Solvents, and Ionic Liquids in Enzyme-Based Biosensors, Bioelectronics and Biomimetics Devices

IF 4.6 Q1 CHEMISTRY, ANALYTICAL
Fhysmélia Firmino de Albuquerque, Rodrigo Michelin Iost and Frank Nelson Crespilho*, 
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引用次数: 0

Abstract

The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES, with their green chemistry credentials and ability to stabilize enzymes under harsh conditions, show great promise, although scalability and performance in complex biological systems remain challenges. ILs, with their superior electron transfer capabilities, enable high sensitivity in electrochemical biosensors, though issues of viscosity and potential toxicity need to be addressed for broader biomedical use. This review provides a comparative analysis of the roles of these materials in enzyme-based biosensors and bioelectronics, including microbatteries and bioelectrosynthesis, highlighting their respective strengths, limitations, and future opportunities. The integration of these materials holds great potential for advancing bioelectronics technologies, with applications spanning medical diagnostics, environmental monitoring, and industrial processes. By addressing current challenges and optimizing these materials for large-scale use, the future of enzyme-based devices could see significant improvements in efficiency, sensitivity, and sustainability.

水凝胶、深度共晶溶剂和离子液体在酶基生物传感器、生物电子学和仿生装置中的比较作用
随着水凝胶、深度共晶溶剂(DES)和离子液体(ILs)等创新材料的引入,基于酶的生物电子器件(包括生物传感器和仿生系统)的发展取得了显著进展。这些材料在提高生物器件性能方面具有独特的优势,特别是在酶稳定性、生物相容性和电化学灵敏度方面。水凝胶以其高含水量和灵活性而闻名,为生物应用中的酶固定化提供了理想的基质,但受低离子电导率的限制。尽管在复杂生物系统中的可扩展性和性能仍然是一个挑战,但DES凭借其绿色化学认证和在恶劣条件下稳定酶的能力,显示出巨大的前景。ILs具有优越的电子转移能力,使得电化学生物传感器具有高灵敏度,但为了更广泛的生物医学应用,需要解决粘度和潜在毒性问题。本文对这些材料在酶基生物传感器和生物电子学(包括微电池和生物电合成)中的作用进行了比较分析,并强调了它们各自的优势、局限性和未来的机会。这些材料的集成在推进生物电子技术方面具有巨大的潜力,应用范围涵盖医疗诊断、环境监测和工业过程。通过解决当前的挑战并优化这些材料以用于大规模使用,未来基于酶的设备可以在效率、灵敏度和可持续性方面取得显着提高。
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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
发文量
0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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