Siamak Moayedi, Andreas Gizaw, Sarah Sweet, Kinjal Sethuraman, Michael Witting
{"title":"Pseudoephedrine prophylaxis does not prevent middle ear barotrauma in hyperbaric oxygen therapy.","authors":"Siamak Moayedi, Andreas Gizaw, Sarah Sweet, Kinjal Sethuraman, Michael Witting","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A common complication of hyperbaric oxygen (HBO₂) treatment is middle ear barotrauma (MEB), which can lead to pain, treatment abandonment, or delay in treatment. Studies have shown that pseudoephedrine decreases MEB for pressure changes in SCUBA divers and airplane travelers. We conducted a randomized, double-blind, placebo-controlled trial to determine if pseudoephedrine effectively decreases MEB rates in patients receiving their first HBO₂ treatment. There was no statistically significant difference between the pseudoephedrine and placebo groups concerning ear pain ratings, tympanic membrane injury, or rescue medication to help equalize ear pressure. Pseudoephedrine prophylaxis, given between 45 minutes and two hours before multiplace HBO₂ treatment, does not mitigate MEB or treatment delays.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"101-107"},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Undersea and Hyperbaric Medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A common complication of hyperbaric oxygen (HBO₂) treatment is middle ear barotrauma (MEB), which can lead to pain, treatment abandonment, or delay in treatment. Studies have shown that pseudoephedrine decreases MEB for pressure changes in SCUBA divers and airplane travelers. We conducted a randomized, double-blind, placebo-controlled trial to determine if pseudoephedrine effectively decreases MEB rates in patients receiving their first HBO₂ treatment. There was no statistically significant difference between the pseudoephedrine and placebo groups concerning ear pain ratings, tympanic membrane injury, or rescue medication to help equalize ear pressure. Pseudoephedrine prophylaxis, given between 45 minutes and two hours before multiplace HBO₂ treatment, does not mitigate MEB or treatment delays.
期刊介绍：
Undersea and Hyperbaric Medicine Journal accepts manuscripts for publication that are related to the areas of diving
research and physiology, hyperbaric medicine and oxygen therapy, submarine medicine, naval medicine and clinical research
related to the above topics. To be considered for UHM scientific papers must deal with significant and new research in an
area related to biological, physical and clinical phenomena related to the above environments.
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