Alik Dakessian, Zachary Hagen, Eugenio R Rocksmith, Kinjal N Sethuraman
{"title":"Definition of delayed-onset neurologic sequelae: A review article.","authors":"Alik Dakessian, Zachary Hagen, Eugenio R Rocksmith, Kinjal N Sethuraman","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Delayed-onset neurologic sequelae (DNS) is a devastating complication of carbon monoxide poisoning. Despite abundant research studies on DNS, the definition remains unclear, with a wide range of symptoms. This review aims to identify the different symptoms and definitions that have been associated with DNS in available research.</p><p><strong>Methods: </strong>For this review, searches were conducted in PubMed and Scopus. Two authors screened research studies by abstract and title, and a third resolved conflicts. After the full-text review, one author extracted the data. Only original full-text research studies in English with a clear definition of DNS were included.</p><p><strong>Results: </strong>This review included 127 studies. Signs and symptoms associated with DNS were categorized into twelve groups. The most used symptom categories to define DNS were general neurological and cognitive/learning dysfunctions. Imaging studies, clinical testing, and neuropsychiatric testing used to define DNS were also documented.</p><p><strong>Conclusions: </strong>The literature did not consistently define DNS attributed to CO toxicity. Standardizing the definition and diagnostic criteria would benefit clinical research.</p>","PeriodicalId":49396,"journal":{"name":"Undersea and Hyperbaric Medicine","volume":"52 2","pages":"121-131"},"PeriodicalIF":0.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Undersea and Hyperbaric Medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MARINE & FRESHWATER BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Delayed-onset neurologic sequelae (DNS) is a devastating complication of carbon monoxide poisoning. Despite abundant research studies on DNS, the definition remains unclear, with a wide range of symptoms. This review aims to identify the different symptoms and definitions that have been associated with DNS in available research.
Methods: For this review, searches were conducted in PubMed and Scopus. Two authors screened research studies by abstract and title, and a third resolved conflicts. After the full-text review, one author extracted the data. Only original full-text research studies in English with a clear definition of DNS were included.
Results: This review included 127 studies. Signs and symptoms associated with DNS were categorized into twelve groups. The most used symptom categories to define DNS were general neurological and cognitive/learning dysfunctions. Imaging studies, clinical testing, and neuropsychiatric testing used to define DNS were also documented.
Conclusions: The literature did not consistently define DNS attributed to CO toxicity. Standardizing the definition and diagnostic criteria would benefit clinical research.
期刊介绍：
Undersea and Hyperbaric Medicine Journal accepts manuscripts for publication that are related to the areas of diving
research and physiology, hyperbaric medicine and oxygen therapy, submarine medicine, naval medicine and clinical research
related to the above topics. To be considered for UHM scientific papers must deal with significant and new research in an
area related to biological, physical and clinical phenomena related to the above environments.
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