Dual-Site Transcranial Direct Current Stimulation Combined With Exercising Improves Fatigue and Sleep Quality in People With Fibromyalgia: A Randomized Sham-Controlled Clinical Trial.
Rafael Velasco-Velasco, Juan Avendaño-Coy, Elena Labrador-García, Elisabeth Bravo-Esteban, Rubén Arroyo-Fernández
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引用次数: 0
Abstract
Objective: The study aimed to evaluate the effectiveness of a combined program of unihemispheric concurrent dual-site anodal-transcranial direct current stimulation (UHCDS a-tDCS) + therapeutic exercise (TE) on fatigue and sleep quality in people with fibromyalgia syndrome (FMS).
Participants: A total of 90 volunteers diagnosed with fibromyalgia. Nine participants dropped out of the study.
Intervention: Participants were randomly allocated in a 1:1:1 ratio to active UHCDS a-tDCS+TE, sham UHCDS a-tDCS+TE, or control receiving TE. The intervention was delivered in 10 sessions over 6 weeks.
Outcome measures: Fatigue, sleep quality, and quality of life.
Results: Fatigue score decreased significantly in the active group compared with the sham (-9.8 points; 95% CI, -18.9 to -0.8; P=.028) and control groups (-9.9 points; 95% CI, -18.9 to -0.9; P=.027) at posttreatment and compared with the control group at follow-up (-11.5 points; 95% CI, -20.8 to -2.1; P=.01). Sleep quality improved in active group compared with sham and control groups at posttreatment (sham: -14.4 points; 95% CI, -24.2 to -4.5; P=.002; control: -19.5 points; 95% CI, -29.4 to -9.7; P<.001) and at follow-up (sham: -11.2 points; 95% CI, -21.1 to -1.3; P=.02; control: -15.5 points; 95% CI, -25.3 to -5.6; P<.001). Quality of life enhanced in the active group compared with the other groups, both at posttreatment (sham: -15.2 points; 95% CI, -26.6 to -3.9; P=.005; control: -13.7 points; 95% CI, 25.0 to -2.3; P=.012) and at follow-up (sham: -14.5 points; 95% CI, -25.2 to -3.7; P=.004; control: -17.4 points; 95% CI, -28.1 to -6.6; P<.001). Effect sizes for intergroup comparisons were medium across all outcomes: fatigue (η²=0.10; P=.01), sleep quality (η²=0.12; P<.01), and quality of life (η²=0.13; P<.01). No intergroup differences in any outcome were found between the sham and control groups.
Conclusions: Combining UHCDS a-tDCS with TE can result in clinically significant improvements in fatigue, sleep disorders, and quality of life in people with FMS.
期刊介绍:
The Archives of Physical Medicine and Rehabilitation publishes original, peer-reviewed research and clinical reports on important trends and developments in physical medicine and rehabilitation and related fields. This international journal brings researchers and clinicians authoritative information on the therapeutic utilization of physical, behavioral and pharmaceutical agents in providing comprehensive care for individuals with chronic illness and disabilities.
Archives began publication in 1920, publishes monthly, and is the official journal of the American Congress of Rehabilitation Medicine. Its papers are cited more often than any other rehabilitation journal.