Syndrome Differentiation and Treatment Patterns of Hypertension in Traditional Chinese Medicine: A Quantitative Literature Analysis

IF 2.4 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-08-18 DOI:10.1155/ijcp/6206443

Xu Xiaotai, Fang Qixiaoxiao

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Abstract

Objective: To analyze clinical studies on the use of traditional Chinese medicine (TCM) in the treatment of primary hypertension through mathematical analysis, aiming to explore the pathogenesis, treatment approaches, and formula patterns in TCM.

Methods: A comprehensive search of both domestic and international databases was conducted to gather randomized controlled trials on TCM for primary hypertension. Data were extracted and analyzed to assess the pathogenesis, treatment strategies, and the frequency of prescription usage in TCM.

Results: A total of nine TCM pathogenesis patterns related to primary hypertension were identified. The three most frequent patterns were hyperactivity of liver yang (54.73%), internal accumulation of phlegm-damp (28.40%), and blood stasis (12.35%). Statistical analysis revealed a significant difference between hyperactivity of liver yang and other pathogenesis patterns (p < 0.05). Eleven treatment strategies related to TCM for this disease were identified. The three most frequent methods were calming the liver and subduing yang (54.73%), resolving phlegm and dampness (28.81%), and tonifying the spleen (20.99%). The method of calming the liver and subduing yang was found to be significantly more effective (p < 0.05). Seventy-five relevant TCM treatment formulas were collected, with the three most commonly used being Tianma Gouteng decoction (20.58%), Banxia Baizhu Tianma decoction (11.93%), and Zhengan Xifeng decoction (4.53%). A significant difference was observed between Tianma Gouteng decoction and other formulas (p < 0.05). The three most frequently used TCMs were Gastrodia elata (81.40%), Ostreae Testa (41.74%), and Mother of Pearl (40.50%). A significant difference was found between Gastrodia elata and other Chinese medicines (p < 0.05).

Conclusion: The primary pathogenesis of primary hypertension is associated with hyperactivity of liver yang and internal accumulation of phlegm-damp. The main treatment strategies are calming the liver and subduing yang, as well as resolving phlegm and dampness. Tianma Gouteng decoction, Banxia Baizhu Tianma decoction, and Zhengan Xifeng decoction are the most frequently used formulas in the treatment of primary hypertension. Gastrodia elata, Ostreae Testa, and Mother of Pearl are the most commonly used TCMs.

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中医高血压辨证论治模式：定量文献分析

目的：通过数理分析分析中医药治疗原发性高血压的临床研究，探讨中医治疗高血压的病机、治疗途径和方剂模式。方法：综合检索国内外数据库，收集中医药治疗原发性高血压的随机对照试验。对数据进行提取和分析，以评估其发病机制、治疗策略和中医处方使用频率。结果：共鉴定出与原发性高血压相关的9种中医病机。最常见的3种类型为肝阳亢（54.73%）、痰湿内积（28.40%）和血瘀（12.35%）。统计分析显示肝阳亢与其他病机型有显著性差异(p <；0.05)。确定了11种与中医相关的治疗策略。最常见的3种方法是平肝降阳（54.73%）、化痰湿（28.81%）和补脾（20.99%）。平肝降阳法疗效明显优于平肝降阳法(p <；0.05)。收集相关中药方剂75种，最常用的3种为天麻勾藤汤（20.58%）、半夏白竹天麻汤（11.93%）和正安西风汤（4.53%）。天麻勾藤汤与其他方比较差异有统计学意义(p <；0.05)。使用频率最高的3种中药分别是天麻（81.40%）、木犀草（41.74%）和珍珠母（40.50%）。天麻与其他中药有显著性差异(p <；0.05)。结论：原发性高血压的主要病机与肝阳上亢、痰湿内积有关。主要的治疗策略是平肝降阳，化痰湿。天麻勾藤汤、半夏白竹天麻汤、正安息风汤是治疗原发性高血压最常用的方剂。天麻、柞蚕和珍珠母是最常用的中药。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.