Development of a New Spark Plasma Sintering Biphasic Calcium Phosphate With Bioglass Composite Ceramics and Examination of Its Biological Activity and Osteogenic Characteristics
Jie Xu, Huifeng Zheng, Wen Li, Yonghong Jian, Feng Liu
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引用次数: 0
Abstract
Bone tissue engineering offers a promising strategy for repairing massive bone defects, with diverse biomaterials continuously emerging in this field. However, the capabilities of single-material systems increasingly fail to meet the requirements for bone regeneration. There is an urgent need to develop novel composite biomaterials. Herein, we fabricate biphasic calcium phosphate (BCP)/bioglass composite ceramics via digital light processing (DLP)-assisted spark plasma sintering (SPS) and systematically evaluate bioglass-ratio-dependent biological activity, biodegradability, and osteogenic efficacy through in vitro and in vivo models. We determined that 45S5 bioglass at 20 wt.% optimally enhances osteogenic differentiation, demonstrating significant potential for bone defect repair in future clinical applications.
期刊介绍：
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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