The association between previous SARS-CoV-2 infection and incidence of stroke

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-07-28 DOI:10.1016/j.ijregi.2025.100716

Naveed Akhtar , Hiam Chemaitelly , Saadat Kamran , Sujatha Joseph , Deborah Morgan , Ryan Uy , Muzna I. Lone , Abdul-Badi Abou-Samra , Laith J. Abu-Raddad , Adeel A. Butt

{"title":"The association between previous SARS-CoV-2 infection and incidence of stroke","authors":"Naveed Akhtar , Hiam Chemaitelly , Saadat Kamran , Sujatha Joseph , Deborah Morgan , Ryan Uy , Muzna I. Lone , Abdul-Badi Abou-Samra , Laith J. Abu-Raddad , Adeel A. Butt","doi":"10.1016/j.ijregi.2025.100716","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To define the association between prior SARS-CoV-2 infection and incidence of stroke.</div></div><div><h3>Methods</h3><div>We conducted a case-control study combining the Qatar stroke database and the Qatar National COVID-19 databases. Cases with stroke diagnosis were matched 1:1 on demographics, comorbidities, and vaccination status to controls who tested negative for SARS-CoV-2 during the same week. Adjusted odds ratios (aORs) comparing the odds of previous documented SARS-CoV-2 infection in cases relative to controls were estimated using conditional logistic regression.</div></div><div><h3>Results</h3><div>Among 1640 matched pairs, 234 (14.3%) previous SARS-CoV-2 infections were recorded among cases and 399 (24.3%) among controls. The aOR (95% confidence interval [CI]) for the association of previous infection with stroke was 0.48 (0.40-0.58). Subgroup analyses revealed aORs of comparable magnitude among those aged 40-59 years and ≥60 years and those with or without coexisting conditions. Those unvaccinated (aOR 0.43; 95% CI 0.29-0.62), vaccinated with two doses (aOR 0.46; 95% CI 0.35-0.60), and vaccinated with three or more doses (aOR 0.63; 95% CI 0.42-0.96) all exhibited similar protective association of previous infection with stroke.</div></div><div><h3>Conclusions</h3><div>Individuals with previous COVID-19 infection are less likely to develop stroke; this finding is not explained by demographic characteristics, comorbidities, or previous vaccination status.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100716"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJID regions","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772707625001511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

To define the association between prior SARS-CoV-2 infection and incidence of stroke.

Methods

We conducted a case-control study combining the Qatar stroke database and the Qatar National COVID-19 databases. Cases with stroke diagnosis were matched 1:1 on demographics, comorbidities, and vaccination status to controls who tested negative for SARS-CoV-2 during the same week. Adjusted odds ratios (aORs) comparing the odds of previous documented SARS-CoV-2 infection in cases relative to controls were estimated using conditional logistic regression.

Results

Among 1640 matched pairs, 234 (14.3%) previous SARS-CoV-2 infections were recorded among cases and 399 (24.3%) among controls. The aOR (95% confidence interval [CI]) for the association of previous infection with stroke was 0.48 (0.40-0.58). Subgroup analyses revealed aORs of comparable magnitude among those aged 40-59 years and ≥60 years and those with or without coexisting conditions. Those unvaccinated (aOR 0.43; 95% CI 0.29-0.62), vaccinated with two doses (aOR 0.46; 95% CI 0.35-0.60), and vaccinated with three or more doses (aOR 0.63; 95% CI 0.42-0.96) all exhibited similar protective association of previous infection with stroke.

Conclusions

Individuals with previous COVID-19 infection are less likely to develop stroke; this finding is not explained by demographic characteristics, comorbidities, or previous vaccination status.

查看原文本刊更多论文

既往SARS-CoV-2感染与卒中发生率之间的关系

目的探讨既往SARS-CoV-2感染与脑卒中发生的关系。方法结合卡塔尔卒中数据库和卡塔尔国家COVID-19数据库进行病例对照研究。卒中诊断病例在人口统计学、合并症和疫苗接种状况方面与同一周内SARS-CoV-2检测阴性的对照组进行1:1匹配。使用条件逻辑回归估计校正优势比（aORs），比较病例中先前记录的SARS-CoV-2感染相对于对照组的几率。结果1640对配对对象中，病例中有234例（14.3%）有SARS-CoV-2感染史，对照组中有399例（24.3%）有SARS-CoV-2感染史。既往感染与卒中相关的aOR（95%可信区间[CI]）为0.48（0.40-0.58）。亚组分析显示，年龄在40-59岁和≥60岁以及有或没有共存疾病的患者中，aORs的幅度相当。未接种疫苗者(aOR 0.43；95% CI 0.29-0.62)，接种两剂疫苗(aOR 0.46；95% CI 0.35-0.60)，接种三剂或三剂以上(aOR 0.63；95% CI 0.42-0.96)均显示出卒中与既往感染相似的保护性关联。结论既往有COVID-19感染的个体发生脑卒中的可能性较低；这一发现不能用人口统计学特征、合并症或以前的疫苗接种状况来解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊