Ceramides and associated key enzymes at the evolutionary crossroad of colorectal inflammatory immune responses and tumorigenesis

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-08-16 DOI:10.1016/j.ijbiomac.2025.146916

Hang Su , Yuan Li , Zongping Li , Sumei Li , Jiashu Pan , Guang Ji , Lu Lu , Hanchen Xu

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引用次数: 0

Abstract

Ceramide is an influential lipid signaling molecule and a key factor in sphingolipid (SL) metabolism; ceramide plays integral roles in the regulation of body metabolism and tumor pathogenesis. Changes in the levels of ceramides and associated enzymes can contribute to metabolic changes and thus cause colorectal cancer (CRC) to enter different survival stages. Elucidating the mechanisms underlying the functions of ceramides and related enzymes in CRC may reveal new therapeutic strategies. In this review, we summarize some of the fundamental mechanisms mediating the effects of ceramide and related enzymes in modulating CRC development via the ceramide-mediated induction of tumor apoptosis, autophagy, proliferation and migration as well as the effects of the key enzymes that are involved in ceramide synthesis and catabolism on the fate of CRC. The aim of this review is to provide novel ideas for developing therapeutic strategies for CRC from a metabolic perspective.

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神经酰胺和相关关键酶在结直肠炎症免疫反应和肿瘤发生的进化十字路口

神经酰胺是一种重要的脂质信号分子，是鞘脂代谢的关键因子；神经酰胺在调节机体代谢和肿瘤发病中起着不可或缺的作用。神经酰胺及相关酶水平的变化可导致代谢变化，从而导致结直肠癌（CRC）进入不同的生存阶段。阐明神经酰胺和相关酶在结直肠癌中的作用机制可能揭示新的治疗策略。本文综述了神经酰胺及其相关酶通过神经酰胺介导的肿瘤凋亡、自噬、增殖和迁移等调控CRC发生的基本机制，以及参与神经酰胺合成和分解代谢的关键酶对CRC命运的影响。本文综述的目的是为从代谢角度开发结直肠癌的治疗策略提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.