Diabetes driven effects on incidence and mortality of breast cancer: A meta-analysis

IF 3.2 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-08-18 DOI:10.1016/j.puhe.2025.105914

Rashmi Rashmi , Richa Singhal , Gauri Misra

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引用次数: 0

Abstract

Objective

This meta-analysis is aimed at investigating the impact of metabolic disorders like diabetes on breast cancer.

Study design

This study is a meta-analysis.

Methods

We searched Scopus, PubMed, and Google Scholar from January 2012 to January 2024 and identified case-control and cohort studies that assessed the incidence of breast cancer or mortality due to it. The analysis included 48 studies using a random effects model to obtain a pooled risk ratio (RR) and 95 % confidence interval (CI). The methodological aspects of selected studies were estimated using the Newcastle-Ottawa Scale (NOS).

Results

Data analysis revealed that diabetes was statistically related to breast cancer with a 20 % increase in breast cancer incidence (RR = 1.203, 95 % CI = 1.135–1.276). This also enhanced the breast cancer mortality (RR = 1.201, 95 % CI = 1.094–1.318). Interestingly, sub-group analysis revealed that breast cancer incidence in Asia was larger as compared to America and Europe (RR = 1.291 in Asia; RR = 1.131 in America; RR = 1.083 in Europe).

Conclusion

This association indicates potential shared pathways and modifiable risk factors connecting these two major non-communicable diseases. Understanding this association is important for prevention and personalized treatment strategies for individuals suffering from these diseases.

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糖尿病对乳腺癌发病率和死亡率的影响：荟萃分析

目的本荟萃分析旨在探讨糖尿病等代谢紊乱对乳腺癌的影响。研究设计本研究为荟萃分析。方法检索2012年1月至2024年1月期间的Scopus、PubMed和谷歌Scholar，确定评估乳腺癌发病率或死亡率的病例对照和队列研究。分析纳入48项研究，采用随机效应模型获得合并风险比（RR）和95%置信区间（CI）。所选研究的方法学方面使用纽卡斯尔-渥太华量表（NOS）进行评估。结果数据分析显示，糖尿病与乳腺癌有统计学相关性，乳腺癌发病率增加20% （RR = 1.203, 95% CI = 1.135 ~ 1.276）。这也增加了乳腺癌死亡率（RR = 1.201, 95% CI = 1.094 ~ 1.318）。有趣的是，亚组分析显示，亚洲的乳腺癌发病率高于美洲和欧洲(RR = 1.291；美国RR = 1.131；欧洲的RR = 1.083)。结论这一关联表明这两种主要非传染性疾病之间存在潜在的共同途径和可改变的危险因素。了解这种关联对于预防和个性化治疗这些疾病非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.