Increased coupling between global grey matter and CSF-derived fMRI signal in young adults after partial sleep deprivation – evidence from the sleepy brain study

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-08-15 DOI:10.1016/j.neuroimage.2025.121420

Cornelius Berberich , Leander Müller , Benedikt Zott , Rachel Nuttal , Gerhard Schneider , Claus Zimmer , Christian Sorg , Dennis M. Hedderich , Juliana Zimmermann

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引用次数: 0

Abstract

Evidence indicates that brain waste clearance happens more efficiently during sleep. Recent studies suggest that the correlation, i.e., coupling, between the cortical grey matter (gGM) blood oxygenation level-dependent signal and cerebrospinal fluid (CSF) signal in the foramen magnum, measured via resting-state functional MRI (fMRI), serves as a non-invasive measure of the ventricular CSF system. Sleep deprivation has been demonstrated to affect brain function and health. Our aim is to assess gGM-CSF coupling after partial sleep deprivation, hypothesizing a change in the coupling measure relative to normal sleep.

To test this hypothesis, we analyzed resting-state fMRI data from 63 healthy participants in the “The Stockholm Sleepy Brain Study”, grouped according to age: younger (20 - 29 years) and older (65 - 75 years) adults. We examined gGM-CSF coupling twice in each subject, in the evening following a night of normal sleep and after a night of partial sleep deprivation (≤ 3 h of sleep).

Our results revealed significantly increased gGM-CSF coupling after sleep deprivation compared to normal sleep (mean r = -0.30 ± 0.19 vs. -0.25 ± 0.14; t(62) = 2.05, p = 0.045). A linear mixed model demonstrated a significant interaction of age with the sleep condition (β = 0.0031, t = 2.73, p = 0.0083), showing significant changes only in the younger subgroup (t(35) = 2.99, p = 0.0050).

These findings indicate that gGM-CSF coupling increases after partial sleep deprivation in younger adults, which may reflect compensatory mechanisms in response to reduced sleep duration. Furthermore, the results suggest that this compensatory response could be diminished in older adults.

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部分睡眠剥夺后，年轻人脑灰质和脑脊液衍生的fMRI信号耦合增加——来自困倦大脑研究的证据

有证据表明，大脑废物的清除在睡眠时更有效。最近的研究表明，通过静息状态功能MRI （fMRI）测量脑枕骨大孔中皮质灰质（gGM）血氧水平依赖性信号与脑脊液（CSF）信号之间的相关性，即耦合，可作为脑脊液系统的非侵入性测量。睡眠不足已被证明会影响大脑功能和健康。我们的目的是评估部分睡眠剥夺后gGM-CSF耦合，假设耦合测量相对于正常睡眠的变化。为了验证这一假设，我们分析了“斯德哥尔摩睡眠大脑研究”中63名健康参与者的静息状态fMRI数据，根据年龄分组：年轻人（20 - 29岁）和老年人（65 - 75岁）。我们在每个受试者中检测了两次gGM-CSF耦合，分别是在正常睡眠后的晚上和部分睡眠剥夺（睡眠≤3小时）后的晚上。我们的研究结果显示，与正常睡眠相比，睡眠剥夺后gGM-CSF耦合显著增加(平均r = -0.30±0.19 vs -0.25±0.14；T (62) = 2.05, p = 0.045)。线性混合模型显示，年龄与睡眠状况之间存在显著的相互作用（β = 0.0031, t = 2.73, p = 0.0083），仅在较年轻的亚组中存在显著变化（t(35) = 2.99, p = 0.0050）。这些发现表明，在年轻人部分睡眠剥夺后，gGM-CSF偶联增加，这可能反映了睡眠时间减少的补偿机制。此外，研究结果表明，这种代偿反应在老年人中可能会减弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.