Biomechanical characterization of cadaveric thigh skin for development of biofidelic simulants

IF 1.4 3区 医学 Q4 ENGINEERING, BIOMEDICAL
Pramod Yadav , Gurpreet Singh , Shubham Gupta , Arnab Chanda
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Abstract

Background

Simulants that accurately replicate the mechanical properties of human skin are essential for biomechanical testing, especially for skin prosthetics and grafting. Although there has been a plethora of research related to the testing of skin samples of several locations, particularly the thigh region remains yet to be extensively explored. Previous studies involving thigh skin lack the testing at varying strain rates which could be helpful to develop simulants and improve high-expansion skin grafts.

Methods

This study focused on developing biofieldic simulants that mimic the realistic mechanical behavior of human skin. Uniaxial tensile tests at various strain rates were conducted on cadaver skin samples. Similar tests were also performed on skin simulants made from a two-part elastomer-based polymer with varying shore hardness. The non-linear responses of these simulants were analyzed using Mooney-Rivlin, Neo-Hookean, and Yeoh hyperelastic models.

Findings

The study found that cadaveric skin exhibited mechanical behavior consistent with existing literature. Simulants of different shore hardness precisely mimic the mechanical behavior of cadaveric skin at various strain rates within a certain strain limit. All curve fittings showed a strong correlation coefficient R-square greater than 0.980.

Interpretation

The mechanical properties of the polymer-based material make them ideal for developing simulants that can be modeled and tuned to closely match real thigh skin. Such highly characterized biofidelic skin simulants could provide novel insights for surgical training, trauma research, mechanical repeatability, and the development of various medical models for skin conditions.
尸体大腿皮肤的生物力学特征用于仿生模拟物的开发
准确复制人体皮肤机械特性的模拟物对于生物力学测试,特别是皮肤修复和移植是必不可少的。虽然已经有大量的研究与测试几个位置的皮肤样本有关,特别是大腿区域仍有待广泛探索。先前涉及大腿皮肤的研究缺乏在不同应变率下的测试,这可能有助于开发模拟物和改善高膨胀皮肤移植物。方法本研究的重点是开发模拟人体皮肤真实力学行为的生物场模拟物。对尸体皮肤样品进行了不同应变速率下的单轴拉伸试验。类似的测试也在由两部分弹性体基聚合物制成的皮肤模拟物上进行,这些聚合物具有不同的肖氏硬度。采用Mooney-Rivlin、Neo-Hookean和Yeoh超弹性模型分析了这些模拟装置的非线性响应。研究发现尸体皮肤表现出与现有文献一致的机械行为。不同邵氏硬度的模拟物可以在一定的应变极限内精确地模拟尸体皮肤在不同应变速率下的力学行为。所有拟合曲线的相关系数均大于0.980。聚合物基材料的机械性能使其成为开发模拟物的理想选择,这些模拟物可以建模和调整,以密切匹配真实的大腿皮肤。这种高度表征的仿生皮肤模拟物可以为外科训练、创伤研究、机械可重复性和各种皮肤疾病医学模型的发展提供新的见解。
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来源期刊
Clinical Biomechanics
Clinical Biomechanics 医学-工程:生物医学
CiteScore
3.30
自引率
5.60%
发文量
189
审稿时长
12.3 weeks
期刊介绍: Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.
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