Corrigendum to “Gas chromatography–trapped ion mobility mass spectrometry: A highly specific and ultra-sensitive platform for quantifying sub-ppt levels of dioxins and PCBs in food” [Chemosphere 385, 2025, 144557]

IF 8.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Chemosphere Pub Date : 2025-08-14 DOI:10.1016/j.chemosphere.2025.144599

Hugo B. Muller, Georges Scholl, Gauthier Eppe

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引用次数: 0

Abstract

In this study, we evaluated the quantitative capabilities of a GC-APCI trapped ion mobility (TIMS) TOF platform for the determination of ultra-trace levels of polychlorinated dibenzo-p-dioxins (PCDD/Fs) and polychlorinated biphenyls (PCBs) in complex food matrices. Using a Bruker timsTOF Pro 2 instrument, three fat-based proficiency test samples - fish oil, palm oil, and milk fat - were analyzed and compared to a validated GC-sectorHRMS method, in accordance with the criteria set by Commission Regulation (EU) 2017/644. Linearity was confirmed across broad dynamic ranges, with relative response factor (RRF) precision consistently below 20 %. Instrumental limits of quantification (iLOQs) reached the 100–500 fg/μL range for dioxins and low pg/μL for PCBs, while method LOQs (mLOQs) were typically in the high fg/g to low pg/g range. Intermediate precision (RSD_R) remained below regulatory thresholds in 97 % of cases. Furthermore, 80 % of PCDD/Fs and over 87 % of PCB measurements met trueness requirements, with summed WHO₂₀₀₅-TEQ and NDL-PCB concentrations in close agreement with sectorHRMS values. Importantly, the addition of the ion mobility dimension provided distinct benefits. It enabled the separation of coeluting isomers (e.g., 2,3,7,8-TCDD), resolved isobaric interferences (e.g., PeCDD and HxCB 169), and allowed for high-confidence analyte identification using collision cross section (CCS) values. CCS differences between native and ¹³C-labeled standards were consistently below 0.5 %, supporting its use as an additional identification criterion. Overall, while the method showed slightly reduced performance for ultra-trace dioxins, it demonstrated accurate quantification and enhanced selectivity, highlighting the strong potential of TIMS-TOF technology for contaminant analysis in food safety applications.

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“气相色谱-捕获离子迁移率质谱法：用于定量食品中二恶英和多氯联苯亚ppt水平的高度特异和超灵敏的平台”[化学环境385,2025,144557]。

在这项研究中，我们评估了GC-APCI捕获离子迁移率（TIMS） TOF平台用于测定复杂食品基质中超痕量多氯二苯并对二恶英（PCDD/Fs）和多氯联苯（pcb）的定量能力。使用Bruker timsTOF Pro 2仪器，根据欧盟委员会法规（EU） 2017/644设定的标准，对三种基于脂肪的熟练度测试样品（鱼油、棕榈油和乳脂）进行分析，并与经过验证的GC-sectorHRMS方法进行比较。在较宽的动态范围内证实线性，相对响应因子（RRF）精度始终低于20%。二恶英的仪器定量限为100 ~ 500 fg/μL，多氯联苯的仪器定量限为低pg/μL，而方法定量限为高fg/g ~低pg/g。在97%的病例中，中间精度（RSDR）仍低于监管阈值。此外，80%的PCDD/Fs和超过87%的PCB测量值符合准确性要求，汇总的WHO2005-TEQ和NDL-PCB浓度与部门hrms值密切一致。重要的是，离子迁移率维度的增加提供了明显的好处。它可以分离共渗异构体（如2,3,7,8- tcdd），解决等压干扰（如PeCDD和HxCB 169），并允许使用碰撞截面（CCS）值进行高置信度的分析物鉴定。本地和13c标签标准之间的CCS差异始终低于0.5%，支持将其用作额外的识别标准。总体而言，虽然该方法对超痕量二恶英的检测性能略有下降，但它具有准确的定量和更高的选择性，突出了TIMS-TOF技术在食品安全污染物分析应用中的强大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemosphere 环境科学-环境科学

CiteScore

15.80

自引率

8.00%

发文量

4975

审稿时长

3.4 months

期刊介绍： Chemosphere, being an international multidisciplinary journal, is dedicated to publishing original communications and review articles on chemicals in the environment. The scope covers a wide range of topics, including the identification, quantification, behavior, fate, toxicology, treatment, and remediation of chemicals in the bio-, hydro-, litho-, and atmosphere, ensuring the broad dissemination of research in this field.