Higher Incidence of Moderate and Severe Congenital Heart Disease in Patients With Neonatal Abstinence Syndrome.

IF 0.7 Q4 NURSING

Neonatal Network Pub Date : 2025-08-01 DOI:10.1891/NN-2024-0036

Zak Webber, Lisa M Grisham, Omar Z Meziab, Andrew W Hoyer, Brent J Barber, Angelina M Price, Scott E Klewer, Tally M Largent-Milnes, Michael D Seckeler

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引用次数: 0

Abstract

Studies suggest that in utero opioid exposure may be associated with congenital heart disease (CHD). We sought to assess the incidence of CHD in infants with neonatal abstinence syndrome (NAS). A review of a national, administrative database from January 2019 to December 2022 was conducted for neonates with an ICD-10 code for NAS and moderate or severe CHD. The incidence of CHD in NAS (the main outcome variable) was compared to those without NAS using χ² analysis and odds ratios for CHD with significant differences. There were 4,994,919 neonatal admissions during the study period: 26,284 with NAS (2.3% had CHD) and 4,968,715 without NAS (1.1% had CHD) (p < .001). Odds ratios for five CHD types (atrioventricular septal defect, aortic coarctation/hypoplastic arch, double-inlet left ventricle, pulmonary valve stenosis, and pulmonary artery stenosis) were higher in NAS. There is the suggestion of a higher incidence of some forms of moderate and severe CHD in neonates with NAS.

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新生儿戒断综合征患者中重度先天性心脏病发病率增高

研究表明，子宫内阿片类药物暴露可能与先天性心脏病（CHD）有关。我们试图评估新生儿戒断综合征（NAS）患儿冠心病的发生率。对2019年1月至2022年12月的国家行政数据库进行了审查，该数据库针对患有中度或重度冠心病和NAS的ICD-10代码的新生儿。NAS组冠心病发生率（主要结局变量）与非NAS组比较，采用χ2分析，冠心病的优势比差异有统计学意义。在研究期间有4,994,919例新生儿入院：26,284例NAS（2.3%患有冠心病）和4,968,715例非NAS（1.1%患有冠心病）（p < 0.001）。5种冠心病类型（房室间隔缺损、主动脉缩窄/发育不全弓、左心室双入口、肺动脉瓣狭窄和肺动脉狭窄）的优势比在NAS组更高。有迹象表明，某些形式的中度和重度冠心病的发生率较高的新生儿与NAS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatal Network NURSING-

CiteScore

0.90

自引率

14.30%

发文量