Long-term exposure to air pollution and liver fibrosis in the elderly with MASLD.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-08-15 DOI:10.1038/s41598-025-15114-5

Yanqi Lan, Haixia Zhang, Ahua Wu, Jiankang Huang, Zhinan Guo, Youlan Chen

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Abstract

This study aimed to investigate the relationship between air pollutants (AP) and liver fibrosis in the older Chinese population with metabolic dysfunction-associated steatotic liver disease (MASLD). A total of 23,887 MASLD subjects aged ≥ 65 years were enrolled in this study. The annual average levels of various APs, including NO₂, SO₂, O₃, CO, and PM, were collected. Logistic regression analysis was conducted to examine the associations between APs and the prevalence of liver fibrosis. The quantile g-computation model was employed to assess the combined effect of the AP mixture. After adjustment for possible confounders, the odds ratios of liver fibrosis at the highest quartile of O₃, CO, SO₂, PM_2.5, and PM₁₀ were 1.50 (1.30, 1.74), 1.26 (1.09, 1.46), 1.22 (1.06, 1.40), 1.49 (1.28, 1.74), and 1.83 (1.56, 2.13) compared to the lowest quartile, respectively. Stratified analysis showed that the effects of APs were more prominent among the males, participants who exercise inactively, those without obesity, and non-diabetic participants (P_{for interaction} < 0.05). The overall AP mixture was positively associated with liver fibrosis, and PM₁₀ mainly contributed to the positive association with liver fibrosis.

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长期暴露于空气污染与老年MASLD肝纤维化的关系

本研究旨在探讨空气污染物（AP）与中国老年代谢功能障碍相关脂肪变性肝病（MASLD）人群肝纤维化之间的关系。本研究共纳入年龄≥65岁的MASLD受试者23,887例。收集了各种ap的年平均水平，包括NO2、SO2、O3、CO和PM。进行Logistic回归分析以检验ap与肝纤维化患病率之间的关系。采用分位数g计算模型评价AP混合剂的综合效果。在对可能的混杂因素进行调整后，与最低四分位数相比，O3、CO、SO2、PM2.5和PM10最高四分位数的肝纤维化比值比分别为1.50（1.30,1.74）、1.26（1.09,1.46）、1.22（1.06,1.40）、1.49（1.28,1.74）和1.83（1.56,2.13）。分层分析显示，APs的作用在男性、不运动的参与者、没有肥胖的参与者和非糖尿病参与者中更为突出（p为相互作用10），主要与肝纤维化呈正相关。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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