Cytotoxic and anticoagulative diterpenoid glycosides from Pteris decrescens

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-08-13 DOI:10.1016/j.phytochem.2025.114643

Chenliang Zhao , Yaxin Yang , Abdullah Al Mamun , Lei Wang , Guangjie Li , Jianghai Ye , Jingjie Zhang , Lutai Pan , Kang He , Juan Zou , Hongjie Zhang

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Abstract

Diterpenoids from the genus Pteris have demonstrated consistent anticancer properties. In the present study, five previously undescribed (1-5) and four known diterpenoids (6–9) were isolated from the 95 % methanol extract of P. decrescens. Among them, decrescensin A (1), represents the first naturally occurring example of a 15(8 → 9)-abeo-ent-kauranoid. The structures of these compounds were established based on their spectroscopic data and single-crystal X-ray diffraction. Compounds 1–9 have been evaluated for their cytotoxic effects against a panel of cancer cell lines including HeLa, HepG2, A549 and SW480. Compound 1 showed significant activity in SW480 cells with an IC₅₀ value of 0.46 μM. In addition, compounds 4 and 6 displayed a mild prolongation effect on activated partial thromboplastin time.

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凤蝶中细胞毒和抗凝二萜苷含量降低。

来自翼蕨属的二萜类化合物已证明具有一致的抗癌特性。在本研究中，从95%甲醇提取物中分离出5个先前未描述的（1-5）和4个已知的二萜（6-9）。其中，decressin A(1)是第一个自然存在的15(8→9)- abo -ent-kauranoid的例子。根据这些化合物的光谱数据和单晶x射线衍射确定了它们的结构。化合物1-9对包括Hela、HepG2、A549和SW480在内的一系列癌细胞的细胞毒作用已被评估。化合物1对SW480细胞有显著活性，IC50值为0.46 μM。此外，化合物4和6对活化的部分凝血活素时间有轻微的延长作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.