Investigation of an Injectable Concentrated Growth Factor Gel for Pulp Tissue Regeneration.

IF 1.5 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2025-08-15 DOI:10.1111/aej.70015

Minghao Wang, Qian Guo, Wanmin Zhao, Zihan Dai, Xiaoru Zhu, Xiaomiao Zhu, Zhihua Wang, Shengchao Wang, Paul Roy Cooper, Wenkai Jiang, Wenxi He

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引用次数: 0

Abstract

Cell homing and stem cell transplantation offers promising approaches for pulp regeneration. This study investigated the efficacy of an injectable concentrated growth factor gel for dental pulp regeneration in beagles. Six groups of beagle teeth were studied: Blank control group, CGF group, Collagen sponge group, CGF + Collagen sponge group, Dental pulp stem cells group, CGF + Dental pulp stem cells group. Specimens were examined by CBCT and histological analysis. No obvious change was identified in the periapical condition. Fewest inflammatory cells were found in the CGF + CS group. Odontoblast-like cells and dentin-like tissue were identified in the root canals of experimental groups, and the thickness of dentin-like tissue was positively correlated with the number of odontoblast-like cells. CD31-positive cells appeared in root canals containing pulp-like tissue. Injectable concentrated growth factor (CGF) can induce in situ pulp-dentin complex regeneration either on its own or in combination with collagen sponge and dental pulp stem cells.

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可注射浓缩生长因子凝胶用于牙髓组织再生的研究。

细胞归巢和干细胞移植为牙髓再生提供了很有前途的方法。本研究探讨了一种可注射的浓缩生长因子凝胶用于小猎犬牙髓再生的效果。选择空白对照组、CGF组、海绵胶原组、CGF +海绵胶原组、牙髓干细胞组、CGF +牙髓干细胞组，共6组。标本行CBCT检查和组织学分析。根尖周围未见明显变化。CGF + CS组炎症细胞最少。实验组根管内均可见成牙本质样细胞和牙本质样组织，牙本质样组织的厚度与成牙本质样细胞的数量呈正相关。含有髓样组织的根管内出现cd31阳性细胞。注射用浓缩生长因子（CGF）可单独或与胶原海绵、牙髓干细胞联合诱导牙本质-牙本质复合体原位再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.