Urinary follicle-stimulating hormone during triptorelin stimulation test can monitor the efficacy of triptorelin depot in girls with precocious or early puberty

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2025-08-01 DOI:10.1016/j.arcped.2025.06.003

Yuan Zhou , Beilei Zeng , Yinyin Huang , Panwang Huang , Ye Li , Zhuangjian Xu , Yaping Ma

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Abstract

Background

There is still no consensus on simple methods to monitor the effectiveness of gonadotropin-releasing hormone analogs in girls with precocious or early puberty.

Objective

To evaluate the value of urinary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) before and after triptorelin stimulation test detected by immunochemiluminometric assay (ICMA) to monitor the efficacy of triptorelin depot in girls with precocious or early puberty.

Methods

A total of 128 girls with precocious or early puberty were included, of whom 81 received triptorelin depot treatment (3.75 mg). Triptorelin (100 μg) stimulation tests were performed before and after 3 months treatment. The time of triptorelin stimulation test was designated as 0 h. Timed 12 h urine with recorded urine volume was collected before and after the test, defined as diurnal spontaneous (-24 h to -12 h), nocturnal spontaneous (-12 h to 0 h), diurnal stimulated (0 h to 12 h), and nocturnal stimulated urine (12 h to 24 h), respectively. LH and FSH were assayed by ICMA.

Results

After 3 months of treatment, 67 girls completed sample collections, with 2 out of 67 girls experiencing inadequate efficacy. Serum and urinary gonadotropin levels decreased significantly after 3 months of treatment. The area under curve (AUC) of nocturnal spontaneous, diurnal stimulated, and nocturnal stimulated urinary FSH (UFSH) concentrations in determining efficacy were 0.962, 0.985, and 0.954. The three AUCs were all greater than serum peak LH (PLH, 0.746) or peak FSH (PFSH, 0.931). When nocturnal spontaneous, diurnal stimulated, and nocturnal stimulated UFSH concentrations were ≤ 5.24 IU/L, 6.94 IU/L, and 5.78 IU/L, the sensitivity was 93.8 %, 96.9 % and 95.4 %, and the specificity was all 100.0 %.

Conclusion

UFSH measured by ICMA from diurnal and nocturnal stimulated 12-hour urine samples can be used to assess the effectiveness of triptorelin depot in girls with precocious or early puberty. For a non-invasive and cost-effective option, spontaneous nocturnal urine may also be a suitable choice.

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雷普多雷林刺激试验期间的尿卵泡刺激素可监测雷普多雷林库在性早熟或性早熟女孩中的疗效。

背景：对于监测促性腺激素释放激素类似物在性早熟或性早熟女孩中的有效性的简单方法仍未达成共识。目的：评价免疫化学发光法（ICMA）检测雷普雷林刺激试验前后的促黄体生成素（LH）和促卵泡激素（FSH）对监测雷普雷林治疗在性早熟或性早熟女孩中的疗效的价值。方法：纳入128例性早熟或性早熟女童，其中81例接受雷普妥林储备治疗（3.75 mg）。治疗3个月前后分别进行雷普妥林（100 μg）刺激试验。雷喜素刺激试验时间为0 h，试验前后收集记录尿量的定时12 h尿，分别定义为昼自发尿（-24 h至-12 h）、夜自发尿（-12 h至0 h）、昼刺激尿（0 h至12 h）、夜刺激尿（12 h至24 h）。采用ICMA法测定LH和FSH。结果：治疗3个月后，67名女孩完成了样本采集，67名女孩中有2名疗效不足。治疗3个月后血清和尿促性腺激素水平明显下降。夜间自发尿促卵泡刺激素、夜间刺激尿促卵泡刺激素和夜间刺激尿促卵泡刺激素测定疗效的曲线下面积（AUC）分别为0.962、0.985和0.954。3个auc均大于血清LH峰（PLH, 0.746）或FSH峰（PFSH, 0.931）。当夜间自发、日间刺激和夜间刺激UFSH浓度≤5.24 IU/L、6.94 IU/L和5.78 IU/L时，敏感性分别为93.8%、96.9%和95.4%，特异性均为100.0%。结论：用ICMA法测定每日和夜间刺激12小时尿液样本的UFSH可用于评价雷普妥林储库治疗性早熟或性早熟女孩的有效性。作为一种非侵入性和成本效益的选择，自发夜间尿也可能是合适的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.