Genetic Associations of Myopia and Axial Length with Diabetic Retinopathy.

IF 1.2 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2025-08-14 DOI:10.1080/09286586.2025.2546322

Jia-Yan Kai, Zhi-Qi Ying, Xing-Xuan Dong, Carla Lanca, Andrzej Grzybowski, Xiao-Feng Zhang, Chen-Wei Pan

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引用次数: 0

Abstract

Purpose: To investigate the genetic associations of myopia and axial length (AL) with diabetic retinopathy (DR).

Methods: We performed Mendelian randomization (MR) analyses using publicly available genome-wide association study (GWAS) summary statistics. Genetic variants were used as instrumental variables. Exposures included myopia, spherical equivalent (SE) and AL. Outcomes of interest included DR, its two subtypes including severe non-proliferative DR (NPDR) and proliferative DR (PDR), and vascular endothelial growth factor (VEGF) levels. The summary statistics for DR and its subtypes were derived from the FinnGen consortium, with over 20,000 participants involved.

Results: A genetically predicted longer AL was significantly protective of PDR (per mm increase in AL: Odds ratio [OR], 0.77; 95% confidence interval [CI], 0.60 to 0.99). There were no significant causal associations of myopia, SE and AL with any DR or severe NPDR (p > 0.05 for all). After pooling the MR results from five different data sources, we found no evidence of causal relationship between AL and VEGF levels (beta, -0.01; 95% CI, -0.08 to 0.06).

Conclusion: Our results suggest a possible causal relationship between an increased AL and a reduced risk of PDR, which may provide insights into novel strategies to prevent PDR.

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近视和眼轴长度与糖尿病视网膜病变的遗传关系。

目的：探讨近视和眼轴长（AL）与糖尿病视网膜病变（DR）的遗传关系。方法：我们使用公开的全基因组关联研究（GWAS）汇总统计数据进行孟德尔随机化（MR）分析。遗传变异被用作工具变量。暴露包括近视，球形当量（SE）和AL。感兴趣的结果包括DR，其两种亚型，包括严重非增殖性DR （NPDR）和增殖性DR (PDR)，以及血管内皮生长因子（VEGF）水平。DR及其亚型的汇总统计数据来自FinnGen联盟，有超过20,000名参与者参与。结果：基因预测的AL较长可显著保护PDR (AL每增加mm)：优势比[OR]， 0.77；95%置信区间[CI]， 0.60 ~ 0.99)。近视、SE和AL与任何DR或严重NPDR均无显著因果关系（p < 0.05）。在汇总了来自五个不同数据源的MR结果后，我们没有发现AL和VEGF水平之间存在因果关系的证据(β, -0.01；95% CI, -0.08 ~ 0.06)。结论：我们的研究结果表明，AL升高与PDR风险降低之间可能存在因果关系，这可能为预防PDR的新策略提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.